MDL 100748
MDL 100748 is an NMDA receptor glycine site antagonist. MDL 100748 modulates NMDA receptor function by acting at the strychnine-insensitive glycine site, which is required for NMDA receptor activation alongside glutamate. MDL 100748 decreases response rates in operant conditioning sessions in phencyclidin (PCP)-trained rats. MDL 100748 can be used for reserach on dementias and schizophrenia.
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- CAS No.: 130613-18-2
- 화학식: C12H8Cl2N2O4
- 분자량:315.11
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Biological Activity
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NMDA Receptor |
MDL 100748 inhibits [3H]glycine binding to NMDA receptor glycine sites in rat brain membranes with an IC50 of 70 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley (adult male; trained to discriminate 2 mg/kg PCP from saline via two-lever operant conditioning under FR32)[1]
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Dosage:1 mg/kg; 1.7 mg/kg; 3 mg/kg
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Administration:i.p.; single dose; 30 minutes prior to test sessions
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Result:Produced 0% PCP-lever selection across all tested doses.
Had an ED50 of 3 mg/kg for suppression of response rates.
Chemical Information
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CAS No. 130613-18-2
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분자량 315.11
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화학식 C12H8Cl2N2O4
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SMILES
O=C(C1=CC(NCC(O)=O)=C2C(Cl)=CC(Cl)=CC2=N1)O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Nicholson KL, et al. The discriminative stimulus effects of N-methyl-D-aspartate glycine-site ligands in NMDA antagonist-trained rats. Psychopharmacology (Berl). 2009;203(2):441-451. [Content Brief]
[2]. Baron BM, et al. Pharmacological characterization of MDL 105,519, an NMDA receptor glycine site antagonist. Eur J Pharmacol. 1997;323(2-3):181-192. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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