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Cat. No.: HY-N17394

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Melineurine

Melineurine is a reversible mixed-type acetylcholinesterase inhibitor, with an IC₅₀ of 95.3 μM against AChE and an IC₅₀ of 28.0 μM against BChE. Melineurine is applicable to the research of Alzheimer's disease.

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CAS No.: 85802-28-4
화학식: C₁₇H₁₇NO₃
분자량:283.32

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Melineurine Chemical Structure

CAS No.: 85802-28-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Cholinesterase (ChE) Isoforms :

AChE
BChE

In Vitro

Melineurine (100 μg/mL) inhibits electric eel acetylcholinesterase with an IC₅₀ of 95.3 μM, with steric hindrance from its 3,3-dimethyl-2-propeneyloxyl substituent reducing its binding affinity compared to more potent acetylcholinesterase inhibitors^[1].
Melineurine (0.1-1.0 μM, 100 μg/mL) inhibits horse serum butyrylcholinesterase with an IC₅₀ of 28.0 μM via a mixed competitive mechanism, with strong binding affinity mediated by multiple hydrogen bonds and hydrophobic interactions with key active site residues^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 85802-28-4
분자량 283.32
화학식 C₁₇H₁₇NO₃
SMILES

COC1=C2C=COC2=NC3=C1C=CC(OC/C=C(C)/C)=C3
Structure Classification
- Alkaloids
- Quinoline Alkaloids
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sichaem J, et al. Furoquinoline Alkaloids from the Leaves of Evodia lepta as Potential Cholinesterase Inhibitors and their Molecular Docking. Nat Prod Commun. 2015;10(8):1359-1362. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

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Melineurine

All Cholinesterase (ChE) Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Melineurine Related Classifications

HY-N17394 Related Classifications