Sodium 2-mercaptoethanesulfonate
Based on 2 publication(s) in Google Scholar
Mesna (Sodium 2-mercaptoethanesulfonate) is an antioxidant which has cytoprotective effects. Mesna is widely used as a systemic protective agent against chemotherapy toxicity. Mesna is also used to reduce hemorrhagic cystitis induced by cyclophosphamide.
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- Purity: 99.90%
- CAS No.: 19767-45-4
- 화학식: C2H5NaO3S2
- 분자량:164.18
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보관:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Sodium 2-mercaptoethanesulfonate
More
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | CC50 |
>400 μM
Compound: mesna
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Cytotoxicity against human HL60 cells in presence of RPMI1640 containing 10% fetal bovine serum by trypan blue exclusion test
Cytotoxicity against human HL60 cells in presence of RPMI1640 containing 10% fetal bovine serum by trypan blue exclusion test
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[PMID: 17499885] |
| HSC-2 | CC50 |
>400 μM
Compound: mesna
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Cytotoxicity against human HSC2 by MTT method
Cytotoxicity against human HSC2 by MTT method
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[PMID: 17499885] |
| HSC-4 | CC50 |
>400 μM
Compound: mesna
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Cytotoxicity against human HSC4 cells by MTT method
Cytotoxicity against human HSC4 cells by MTT method
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[PMID: 17499885] |
| L1210 | IC50 |
>200 μM
Compound: Mesna
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Concentration required to reduce the viability of L1210 cells by 50% after 1-h incubation at 37 degrees C
Concentration required to reduce the viability of L1210 cells by 50% after 1-h incubation at 37 degrees C
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[PMID: 1992116] |
Mesna (1-1000 μM) reduces H2O2, HOCl and OH concentrations in a dose-dependent manner, with an IC50 of 32, 21, and 305 μM, respectively in cell-free experiments[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Mesna (200 mg/kg; a single i.p.) attenuates the cisplatin-induced ovarian damages in rats[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult male Wistar Albino rats (250-350 g) are suffered traumatic brain injury (TBI)[1]
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Dosage:150 mg/kg
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Administration:A single i.p.
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Result:Decreased tissue malondialdehyde levels.
Increased the activity of glutathione peroxidase and superoxide dismutase.
Decreased the levels of nitric oxide, nitric oxide synthetase and xanthine oxidase.
Protected the brain tissues well from injury.
Chemical Information
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CAS No. 19767-45-4
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Appearance Solid
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분자량 164.18
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화학식 C2H5NaO3S2
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Color White to off-white
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SMILES
SCCS(=O)(O[Na])=O
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Synonyms
Mesnum
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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Nat Cell Biol
TOLLIP targets GSDME-NT-carrying endocytic vesicles for autophagy to regulate pyroptosis and chemotherapy efficacy. [Abstract]2026 Apr;28(4):812-827. PMID: 41803502 -
Cell Rep
Cholesterol suppresses GOLM1-dependent selective autophagy of RTKs in hepatocellular carcinoma. [Abstract]2022 Apr 19;39(3):110712. PMID: 35443161
용액&용해도
DMSO : 100 mg/mL (609.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 50 mg/mL (304.54 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (609.09 mM); Clear solution; Need ultrasonic
순도&문서
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Data Sheet (275 KB)
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SDS (394 KB)
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- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Mesna (2-mercaptoethane sodium sulfonate) functions as a regulator of myeloperoxidase
[2]. Yilmaz ER, Kertmen H, Gürer B, The protective effect of 2-mercaptoethane sulfonate (MESNA) against traumatic brain injury in rats. Acta Neurochir (Wien). 2013 Jan;155(1):141-9; discussion 149. [Content Brief]
[3]. Li X, Yang S, Lv X, The mechanism of mesna in protection from cisplatin-induced ovarian damage in female rats. J Gynecol Oncol. 2013 Apr;24(2):177-85. [Content Brief]
[4]. Gressier B, et, al. Scavenging of reactive oxygen species by letosteine, a molecule with two blocked-SH groups. Comparison with free-SH drugs. Pharm World Sci. 1995 May 26;17(3):76-80. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 6.0909 mL | 30.4544 mL | 60.9088 mL | 152.2719 mL |
| 5 mM | 1.2182 mL | 6.0909 mL | 12.1818 mL | 30.4544 mL | |
| 10 mM | 0.6091 mL | 3.0454 mL | 6.0909 mL | 15.2272 mL | |
| 15 mM | 0.4061 mL | 2.0303 mL | 4.0606 mL | 10.1515 mL | |
| 20 mM | 0.3045 mL | 1.5227 mL | 3.0454 mL | 7.6136 mL | |
| 25 mM | 0.2436 mL | 1.2182 mL | 2.4364 mL | 6.0909 mL | |
| 30 mM | 0.2030 mL | 1.0151 mL | 2.0303 mL | 5.0757 mL | |
| 40 mM | 0.1523 mL | 0.7614 mL | 1.5227 mL | 3.8068 mL | |
| 50 mM | 0.1218 mL | 0.6091 mL | 1.2182 mL | 3.0454 mL | |
| 60 mM | 0.1015 mL | 0.5076 mL | 1.0151 mL | 2.5379 mL | |
| 80 mM | 0.0761 mL | 0.3807 mL | 0.7614 mL | 1.9034 mL | |
| 100 mM | 0.0609 mL | 0.3045 mL | 0.6091 mL | 1.5227 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Sodium 2-mercaptoethanesulfonate Related Classifications
HY-13679 Related Classifications
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