Mexiprostil
Mexiprostil (MDL 646) is an orally active gastric protectant, being a synthetic analogue of Prostaglandin E1 (HY-B0131). Mexiprostil exhibits significant inhibition of gastric acid secretion caused by Histamine (HY-B1204) and Bethanechol (HY-B0406) in rats, dogs, and cats. Mexiprostil can also inhibit the increase in gastric acid secretion caused by Pentagastrin (HY-A0261) in cats, while it does not have this effect in dogs and rats. Mexiprostil does not cause pregnancy termination. Mexiprostil can be used for research on gastric ulcers.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 88980-20-5
- 화학식: C23H40O6
- 분자량:412.56
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Chemical Information
-
CAS No. 88980-20-5
-
분자량 412.56
-
화학식 C23H40O6
-
SMILES
CCCCC(OC)(C)[C@H](O)/C=C/[C@@H]1[C@H](C(C[C@H]1O)=O)CCCCCCC(OC)=O
-
Synonyms
MDL 646
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Müller P, et al. An alprostadil analogue and human gastric secretion. A double-blind placebo-controlled study of the effects of a capsule and tablet formulation. Arzneimittelforschung. 1989 Jul;39(7):809-11. [Content Brief]
[2]. Scarpignato C, et al. Action of MDL 646, a new synthetic prostaglandin, on gastric acid secretion of some experimental animals. Res Commun Chem Pathol Pharmacol. 1983 Feb;39(2):211-28. [Content Brief]
[3]. Galliani G, et al. Studies on the luteolytic activity of MDL-646, a new gastroprotective PGE1 analogue, in the hamster. Prostaglandins. 1984 Apr;27(4):583-90. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)