Miptenalimab
Based on 1 publication(s) in Google Scholar
Miptenalimab (BI-754111) is an anti-human LAG-3 antibody (KD: 88.6 nM for h LAG-3). Miptenalimab blocks the interaction of LAG-3 with its ligand MHC-II.
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- Purity : 97.04%
- CAS No.: 2249882-55-9
- 분자량:145.84 kDa
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) Miptenalimab
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Biological Activity
제품 설명
Isotype
Human IgG4 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
LAG3/CD223
In Vitro
Miptenalimab blocks binding of soluble hLAG-3 to MHC-II-expressing Raji cells (IC90: 2.1 nM)[1].
Miptenalimab increases IL-2 secretion of the mouse cell line 3A9-hLAG-3 (EC50: 0.31 nM), and also increases IFN-γ secretion[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG4 kappa
신청
ELISA, FACS, Functional assay
Verified Bioactivity
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Immobilized LAG-3 Protein, Human (HEK293, His, HY-P70722) can bind Miptenalimab. The EC50 for this effect is 673.3 ng/mL. -
Flow cytometric analysis of 1X106 Jurkat cells labeling Miptenalimab (HY-P99736, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
Chemical Information
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CAS No. 2249882-55-9
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Appearance Liquid
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분자량 145.84 kDa
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Color Colorless to light yellow
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SMILES
[Miptenalimab]
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Synonyms
BI-754111
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선적
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
-
Most Recent
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Sci Rep
Targeting LAG3 to alter the tumor immune reactivity of CD8+T cells is a potential therapy for skin cutaneous melanoma. [Abstract]2025 Oct 29;15(1):37910. PMID: 41162565
순도&문서
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Data Sheet (258 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)