MPP+-d3 iodide
Based on 1 Customer Validation
MPP+-d3 (iodide) is deuterium labeled MPP+ (iodide). MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT).
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- Purity: 99.21%
- CAS No.: 207556-07-8
- 화학식: C12H9D3IN
- 분자량:300.15
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보관:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 207556-07-8
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Unlabeled Cas 36913-39-0
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Appearance Solid
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분자량 300.15
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화학식 C12H9D3IN
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Color Off-white to light yellow
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SMILES
[2H]C([2H])([2H])[N+]1=CC=C(C2=CC=CC=C2)C=C1.[I-]
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
용액&용해도
DMSO : 100 mg/mL (333.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (274 KB)
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SDS (421 KB)
- English - EN (421 KB)
- Français - FR (421 KB)
- Deutsch - DE (421 KB)
- Norwegian - NO (421 KB)
- Español - ES (421 KB)
- Swedish - SV (421 KB)
- Italian - IT (421 KB)
- Korean - KR (421 KB)
- Portuguese - PT (421 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Zhao M, et al. Mitochondrial calcium dysfunction contributes to autophagic cell death induced by MPP+ via AMPK pathway. Biochem Biophys Res Commun. 2019;509(2):390-394. [Content Brief]
[3]. Martí Y, et al. Methyl-4-phenylpyridinium (MPP+) differentially affects monoamine release and re-uptake in murine embryonic stem cell-derived dopaminergic and serotonergic neurons. Mol Cell Neurosci. 2017;83:37-45. [Content Brief]
[4]. Charlton CG. 1-Methyl-4-phenylpyridinium (MPP+) but not 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) serves as methyl donor for dopamine: a possible mechanism of action. J Geriatr Psychiatry Neurol. 1992;5(2):114-118. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3317 mL | 16.6583 mL | 33.3167 mL | 83.2917 mL |
| 5 mM | 0.6663 mL | 3.3317 mL | 6.6633 mL | 16.6583 mL | |
| 10 mM | 0.3332 mL | 1.6658 mL | 3.3317 mL | 8.3292 mL | |
| 15 mM | 0.2221 mL | 1.1106 mL | 2.2211 mL | 5.5528 mL | |
| 20 mM | 0.1666 mL | 0.8329 mL | 1.6658 mL | 4.1646 mL | |
| 25 mM | 0.1333 mL | 0.6663 mL | 1.3327 mL | 3.3317 mL | |
| 30 mM | 0.1111 mL | 0.5553 mL | 1.1106 mL | 2.7764 mL | |
| 40 mM | 0.0833 mL | 0.4165 mL | 0.8329 mL | 2.0823 mL | |
| 50 mM | 0.0666 mL | 0.3332 mL | 0.6663 mL | 1.6658 mL | |
| 60 mM | 0.0555 mL | 0.2776 mL | 0.5553 mL | 1.3882 mL | |
| 80 mM | 0.0416 mL | 0.2082 mL | 0.4165 mL | 1.0411 mL | |
| 100 mM | 0.0333 mL | 0.1666 mL | 0.3332 mL | 0.8329 mL |
MPP+-d3 iodide Related Classifications
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