N-Acetylmuramic acid
Based on 1 Customer Validation
N-acetylmuramic acid is a component of the bacterial cell wall peptidoglycan, essential for maintaining cell shape and integrity. N-acetylmuramic acid inhibits spore germination by inhibiting a coat-associated hexosaminidase and a core enzyme. N-acetylmuramic acid is required by Bacteroides forsythus for proliferation and the maintenance of its cell shape. N-Acetylmuramic acid inhibits the p38 MAPK/NF-κB signaling pathway, and exhibits anti-inflammatory activity. N-Acetylmuramic acid is orally active.
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- Purity : 99.9%
- CAS No.: 10597-89-4
- 화학식: C11H19NO8
- 분자량:293.27
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보관:
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Biological Activity
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Chemical Information
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용액&용해도
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
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Human Endogenous Metabolite |
In Vitro
N-Acetylmuramic acid (0.1-10 mg/L, 5 days) destroys the cell wall, enables the normal growth of B. forsythus and the formation of a typical filamentous morphology[3].
N-Acetylmuramic acid (100-300 μg/mL, 18 h) reduces the expressions of iNOS and COX-2, inhibits and the secretion of TNF-α and IL-1β in LPS (HY-D1056)-stimulated RAW264.7 cell[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW264.7
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Concentration:100-300 μg/mL
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Incubation Time:48 h
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Result:Inhibited the expression of iNOS and COX-2.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:E. coli-infected mouse models[4]
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Dosage:10-40 mg/kg
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Administration:po, once daily for 25 days
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Result:Inhibited E. coli-induced villus edema and thickening, increased the level of sIgA in mouse intestine.
Chemical Information
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CAS No. 10597-89-4
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Appearance Solid
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분자량 293.27
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화학식 C11H19NO8
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Color White to off-white
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SMILES
CC(N[C@@H](C=O)[C@@H](O[C@H](C)C(O)=O)[C@H](O)[C@H](O)CO)=O
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Synonyms
MurNAc; NAMA
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
용액&용해도
In Vitro:
H2O : 100 mg/mL (340.98 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
순도&문서
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Data Sheet (278 KB)
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SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
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Handling Instructions (2659 KB)
References
[1]. Herbold DR, Glaser L. Interaction of N-acetylmuramic acid L-alanine amidase with cell wall polymers. J Biol Chem. 1975 Sep 25;250(18):7231-8 [Content Brief]
[2]. Brown W, et al. N-acetylmuramic acid inhibits spore germination and germination enzymes. J Basic Microbiol. 1990;30(2):67-72 [Content Brief]
[3]. Wyss C. Dependence of proliferation of Bacteroides forsythus on exogenous N-acetylmuramic acid. Infect Immun. 1989 Jun;57(6):1757-9 [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 3.4098 mL | 17.0491 mL | 34.0983 mL | 85.2457 mL |
| 5 mM | 0.6820 mL | 3.4098 mL | 6.8197 mL | 17.0491 mL | |
| 10 mM | 0.3410 mL | 1.7049 mL | 3.4098 mL | 8.5246 mL | |
| 15 mM | 0.2273 mL | 1.1366 mL | 2.2732 mL | 5.6830 mL | |
| 20 mM | 0.1705 mL | 0.8525 mL | 1.7049 mL | 4.2623 mL | |
| 25 mM | 0.1364 mL | 0.6820 mL | 1.3639 mL | 3.4098 mL | |
| 30 mM | 0.1137 mL | 0.5683 mL | 1.1366 mL | 2.8415 mL | |
| 40 mM | 0.0852 mL | 0.4262 mL | 0.8525 mL | 2.1311 mL | |
| 50 mM | 0.0682 mL | 0.3410 mL | 0.6820 mL | 1.7049 mL | |
| 60 mM | 0.0568 mL | 0.2842 mL | 0.5683 mL | 1.4208 mL | |
| 80 mM | 0.0426 mL | 0.2131 mL | 0.4262 mL | 1.0656 mL | |
| 100 mM | 0.0341 mL | 0.1705 mL | 0.3410 mL | 0.8525 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
N-Acetylmuramic acid Related Classifications
HY-W009274 Related Classifications
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