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Nedosiran

(Synonyms: DCR-PHXC)
1 Cited Publications
고객리뷰

Based on 1 publication(s) in Google Scholar

Nedosiran (DCR-PHXC) is an RNA interference (RNAi) targeting lactate dehydrogenase (LDH). Nedosiran represents an impactful potential therapeutic for primary hyperoxaluria (PH) with end-stage renal disease (ESRD). Nedosiran is a GalNAc-dsRNA conjugate.

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  • Purity: 92.35%
  • CAS No.: 2266591-83-5
  • 화학식: C662H865F19N231O413P57S6
  • 분자량:20985.12
  • 보관:

    -20°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Nedosiran Chemical Structure
    Nedosiran Chemical Structure
CAS No.: 2266591-83-5
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  • Nedosiran Chemical Structure
    Nedosiran Chemical Structure RNA,(Am-sp-Um-(2'-deoxy-2'-fluoro)G-Um-(2'-deoxy-2'-fluoro)U-Gm-Um-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)U-Um-(2'-deoxy-2'-fluoro)U-Um-(2'-deoxy-2'-fluoro)A-Um-(2'-deoxy-2'-fluoro)C-Um-Gm-Am-Gm-Cm-Am-GmCm-Cm-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]G-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-Dgalactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-Dgalactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-Gm-Gm-Cm-Um-GmCm), complex with RNA ([1-de-β-D-ribofuranosyl-1-[(2R,3R,4S,5S)-tetrahydro-4-hydroxy-5-[(hydroxymethoxyphosphinyl)methoxy]-3-methoxy-2-furanyl]]U-(4'→5')- sp-(2'-deoxy-2'-fluoro)C-sp-(2'-deoxy-2'-fluoro)A-sp-(2'-deoxy-2'-fluoro)G- (2'-deoxy-2'-fluoro)A-Um-(2'-deoxy-2'-fluoro)A-Am-(2'-deo
    1/16
  • RNA,(Am-sp-Um-(2'-deoxy-2'-fluoro)G-Um-(2'-deoxy-2'-fluoro)U-Gm-Um-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)U-Um-(2'-deoxy-2'-fluoro)U-Um-(2'-deoxy-2'-fluoro)A-Um-(2'-deoxy-2'-fluoro)C-Um-Gm-Am-Gm-Cm-Am-GmCm-Cm-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]G-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-Dgalactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-Dgalactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-Gm-Gm-Cm-Um-GmCm), complex with RNA ([1-de-β-D-ribofuranosyl-1-[(2R,3R,4S,5S)-tetrahydro-4-hydroxy-5-[(hydroxymethoxyphosphinyl)methoxy]-3-methoxy-2-furanyl]]U-(4'→5')- sp-(2'-deoxy-2'-fluoro)C-sp-(2'-deoxy-2'-fluoro)A-sp-(2'-deoxy-2'-fluoro)G- (2'-deoxy-2'-fluoro)A-Um-(2'-deoxy-2'-fluoro)A-Am-(2'-deo