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Cat. No.: HY-164503

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Neptinib

(Synonyms: NEP010)

Neptinib (NEP010) is an orally active derivative of Afatinib (HY-10261) that has stronger antitumor activity than Afatinib (HY-10261) by improving pharmacokinetics. Neptinib has a significant inhibitory effect on tumor growth in mouse non-small cell lung cancer models with different EGFR mutations. Neptinib has a certain inhibitory effect on the EGFR kinase family, with IC₅₀ values ??of 0.24 nM, 7.25 nM, 0.46 nM and 1.79 nM for EGFR^wt, EGFR^L858R/T790M, EGFR^L858R and EGFR^T790M, respectively.

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CAS No.: 2085843-51-0
화학식: C₂₂H₂₃ClFN₅O₂
분자량:443.90

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Neptinib Chemical Structure

CAS No.: 2085843-51-0

사이즈

가격

재고

수량

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Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

EGFR (WT)

0.24 nM (IC₅₀)

EGFR^L858R/T790M

7.25 nM (IC₅₀)

EGFR^L858R

0.46 nM (IC₅₀)

EGFR^T790M

1.79 nM (IC₅₀)

All EGFR Isoforms :

Chemical Information

CAS No. 2085843-51-0
분자량 443.90
화학식 C₂₂H₂₃ClFN₅O₂
SMILES

FC(C=C1)=C(Cl)C=C1NC2=NC=NC3=C2C=C(NC(/C=C/CN(C)C)=O)C(OCC)=C3
Synonyms

NEP010
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yidong Feng, et al. "NEP010, a novel compound with minor structural modification from afatinib, exhibited significantly improved antitumor activity." European Journal of Pharmacology 946 (2023): 175620. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
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상품명:
CAS No.:
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Purity:
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Neptinib

High-Throughput Bioactive Compound Library

All EGFR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Neptinib Related Classifications

HY-164503 Related Classifications