NS 1231
NS 1231 is a neurotrophic-like compound with neuroprotective effect. NS 1231 can rescue nerve growth factor (NGF)-differentiated PC12 cells from death induced by withdrawal of trophic factors. NS 1231 can stimulate NGF-induced neurite outgrowth of undifferentiated PC12 cells. NS 1231 can be used for the research of neurological disease, such as stroke.
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- CAS No.: 309711-72-6
- 화학식: C18H15ClN2O2
- 분자량:326.78
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
NS 1231 (1-10 μM) increases the viability of NGF-differentiated PC12 cells and preserves the neurites of surviving cells when administered for 4 days after trophic factor (serum and NGF) withdrawal[1].
NS 1231 (1-3 μM, 48 h) in combination with NGF significantly stimulates neurite outgrowth in undifferentiated PC12 cells[1].
NS 1231 (1-3 μM, 5 mins) in combination with NGF enhances NGF-induced TrkA phosphorylation at the Shc-binding site (Tyr490) and ERK activation (Thr202/Tyr204) in undifferentiated PC12 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice with middle cerebral artery occlusion (MCAO)[1]
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Dosage:15 mg/kg
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Administration:Intraperitoneally injection, 2 mins after MCAO
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Result:Reduced the total infarct volume by 43% after 4 days.
Chemical Information
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CAS No. 309711-72-6
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분자량 326.78
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화학식 C18H15ClN2O2
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SMILES
O=C1NC2=C(C=C(C3=CC=C(Cl)C=C3)C4=C2CCCC4)/C1=N/O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NS 1231 Related Classifications
HY-165616 Related Classifications
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