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Cat. No.: HY-180498

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NSC 57148

NSC 57148 is a selective Grb7 SH2 domain antagonist with an IC₅₀ value of 1.1 μM. NSC 57148 reduces cancer cell proliferation and migration. NSC 57148 is promising for research of Grb7-overexpressing malignancies such as breast and pancreatic cancers.

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CAS No.: 4315-44-0
화학식: C₂₈H₃₀Cl₂N₆O₂
분자량:553.48

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

NSC 57148 Chemical Structure

CAS No.: 4315-44-0

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Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity

제품 설명

All EGFR Isoforms :

Chemical Information

CAS No. 4315-44-0
분자량 553.48
화학식 C₂₈H₃₀Cl₂N₆O₂
SMILES

O=C(C1=CC=C(C(NC2=CC=C(C3=NC(CN3)C)C=C2)=O)C=C1)NC4=CC=C(C5=NC(CN5)C)C=C4.Cl.Cl
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ambaye ND, et al. The discovery of phenylbenzamide derivatives as Grb7-based antitumor agents. ChemMedChem. 2013 Feb;8(2):280-8. [Content Brief]

Calculators

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Molecular Weight Molecular Weight

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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Chemical Information
순도&문서
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NSC 57148

All EGFR Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

NSC 57148 Related Classifications

HY-180498 Related Classifications