Ophiobolin A
Based on 1 Customer Validation
Ophiobolin A, a fungal metabolite and a phytotoxin, is a potent and irreversibly inhibitor of calmodulin-activated cyclic nucleotide phosphodiesterase, with an IC50 value of 9 μM. Ophiobolin A antimicrobial and anticancer activity.
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- Purity : 98.86%
- CAS No.: 4611-05-6
- 화학식: C25H36O4
- 분자량:400.55
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보관:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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용액&용해도
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
IC50: 9 μM (calmodulin-activated cyclic nucleotide phosphodiesterase)[1].
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | GI50 |
0.1 μM
Compound: Ophiobolin A
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Antiproliferative activity against human A549 cells by MTT assay
Antiproliferative activity against human A549 cells by MTT assay
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[PMID: 26341136] |
| A549 | IC50 |
50 ng/mL
Compound: 2
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Cytotoxicity against human A549 cells
Cytotoxicity against human A549 cells
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[PMID: 10395513] |
| B16-F10 | IC50 |
0.29 μM
Compound: 3
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Antiproliferative activity against mouse B16-F10 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against mouse B16-F10 cells assessed as reduction in cell viability after 72 hrs by MTT assay
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[PMID: 33074690] |
| Hs 683 | GI50 |
0.02 μM
Compound: Ophiobolin A
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Antiproliferative activity against human Hs683 cells by MTT assay
Antiproliferative activity against human Hs683 cells by MTT assay
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[PMID: 26341136] |
| HT-29 | IC50 |
50 ng/mL
Compound: 2
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Cytotoxicity against human HT-29 cells
Cytotoxicity against human HT-29 cells
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[PMID: 10395513] |
| MCF7 | GI50 |
0.06 μM
Compound: Ophiobolin A
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Antiproliferative activity against human MCF7 cells by MTT assay
Antiproliferative activity against human MCF7 cells by MTT assay
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[PMID: 26341136] |
| P388 | IC50 |
25 ng/mL
Compound: 2
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Cytotoxicity against mouse P388 cells
Cytotoxicity against mouse P388 cells
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[PMID: 10395513] |
| Panel NCI-60 (60 carcinoma cell lines) | GI50 |
72 nM
Compound: 1
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Cytotoxicity against human NCI60 cells
Cytotoxicity against human NCI60 cells
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[PMID: 30765189] |
| SK-MEL-28 | GI50 |
0.05 μM
Compound: Ophiobolin A
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Antiproliferative activity against human SK-MEL-28 cells by MTT assay
Antiproliferative activity against human SK-MEL-28 cells by MTT assay
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[PMID: 26341136] |
| U-373MG ATCC | GI50 |
0.06 μM
Compound: Ophiobolin A
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Antiproliferative activity against human U373 cells by MTT assay
Antiproliferative activity against human U373 cells by MTT assay
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[PMID: 26341136] |
Chemical Information
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CAS No. 4611-05-6
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Appearance Solid
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분자량 400.55
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화학식 C25H36O4
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Color White to off-white
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SMILES
O=C/C1=C/C[C@]2([H])[C@@](CC[C@@]23O[C@@H](/C=C(C)\C)C[C@@H]3C)(C)C[C@@]4([H])[C@]1([H])C(C[C@]4(O)C)=O
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Structure Classification
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Initial Source
fungus Bipolaris sp.
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
용액&용해도
In Vitro:
Methanol : 4 mg/mL (9.99 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
순도&문서
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Data Sheet (272 KB)
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SDS (479 KB)
- English - EN (479 KB)
- Français - FR (479 KB)
- Deutsch - DE (479 KB)
- Norwegian - NO (479 KB)
- Español - ES (479 KB)
- Swedish - SV (479 KB)
- Italian - IT (479 KB)
- Korean - KR (479 KB)
- Portuguese - PT (479 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Methanol | 1 mM | 2.4966 mL | 12.4828 mL | 24.9657 mL | 62.4142 mL |
| 5 mM | 0.4993 mL | 2.4966 mL | 4.9931 mL | 12.4828 mL |
Ophiobolin A Related Classifications
HY-N6781 Related Classifications
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