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Cat. No.: HY-182357

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PAK1-IN-3

PAK1-IN-3 is a PAK1 inhibitor with an IC₅₀ of 10 nM, an IC₅₀ of 20 nM against PAK2, and an IC₅₀ of 1079 nM against hERG potassium channels. PAK1-IN-3 forms a salt bridge with Asp106 in PAK1 via a properly positioned tertiary amine. PAK1-IN-3 inhibits PAK2 and hERG potassium channels.

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화학식: C₂₇H₃₁ClN₈O₂
분자량:535.04

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

PAK1-IN-3 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

PAK1

10 nM (IC₅₀)

PAK2

20 nM (IC₅₀)

All PAK Isoforms :

In Vitro

PAK1-IN-3 (Compound 12) has a logD_7.4 of 3.02, moderate solubility in PBS pH 7.4, high plasma protein binding, parent-like metabolic stability in human hepatocytes, and efflux ratios of 0.7 in MDCKII cells and 2.9 in Caco-2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

분자량 535.04
화학식 C₂₇H₃₁ClN₈O₂
SMILES

O=C1C(C2=CC=C(C3=NC(C)=CN=C3)C=C2Cl)=CC4=CN=C(NCCN5OCCN(C)CC5)N=C4N1CC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Khan I, et al. Endocyclic Trisubstituted Hydroxylamine Isosteres of Basic Amines for ADME Modulation and Reduction of hERG Activity. ACS Medicinal Chemistry Letters, 2026.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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PAK1-IN-3

All PAK Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

PAK1-IN-3 Related Classifications

HY-182357 Related Classifications