PCC16 chloride

PCC16 (0.1-50 μM; 6 h) chloride degrades DHHC3 and PD-L1 in C33A cells with a DC₅₀ of 0.103 μM for PD-L1 degradation, showing potent activity even at 0.1 μM after 6-hour incubation^[1].
PCC16 (1 μM; 1-24 h) chloride induces significant degradation of DHHC3 and PD-L1 in C33A cells after 4-hour incubation, with greater degradation observed at extended incubation times up to 24 h^[1].
PCC16(0.1-50 μM) chloride reduces PD-L1 protein levels in a concentration-dependent manner in U14, CT26, and B16F10 cells^[1].
PCC16 (2.5 μM; 6 h) chloride colocalizes with DHHC3 protein in C33A cells, demonstrating stable binding affinity to the target^[1].
PCC16 (0.5 μM) chloride binds to DHHC3 in C33A cells, increasing the protein's thermal stability and shifting its degradation temperature from 49 °C to 55 °C^[1].
PCC16 (0.1-50 μM; 24 h and 1 μM; 1-24 h) chloride exhibits low cytotoxicity in C33A cells, with no significant reduction in cell viability observed at concentrations up to 50 μM (24-hour incubation) or over incubation times up to 24 h (1 μM concentration)^[1].
PCC16 chloride enhances the sensitivity of C33A cells to cisplatin, significantly reducing cell proliferation and increasing apoptosis when combined with cisplatin treatment^[1].
PCC16 (1-10 μM; 6 h) chloride increases IFN-γ and TNF-α secretion and enhances T-cell-mediated killing of C33A cells in a concentration-dependent manner in a T-cell-C33A co-culture system^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.