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Cat. No.: HY-169232

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PCC16 chloride

PCC16 chloride is a CRBN-based cp-PCC with an IC₅₀ value of 102 nM for the degradation of DHHC3. PCC16 chloride has antitumor activity.
(Pink: DHHC3 ligand (HY-169235); Blue: Cereblon ligand (HY-10984); Black: linker (HY-169236)).

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₂₀₆H₃₂₂ClN₆₇O₆₀S
분자량:4764.69

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

PCC16 chloride Chemical Structure

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

PCC16 chloride is a CRBN-based cp-PCC with an IC₅₀ value of 102 nM for the degradation of DHHC3. PCC16 chloride has antitumor activity^[1]. (Pink: DHHC3 ligand (HY-169235); Blue: Cereblon ligand (HY-10984); Black: linker (HY-169236)).

All PROTACs Isoforms :

Chemical Information

분자량 4764.69
화학식 C₂₀₆H₃₂₂ClN₆₇O₆₀S
Sequence

{Rhodmine B}-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Cys-Gly-Ile-Gln-Asp-Thr-Asn-Ser-Lys-Lys-Gln-Ser-Asp-Thr-His-Leu-Glu-Glu-Thr-{Lys(pomalidomide-Suc-PEG2)}-NH2
Sequence Shortening

{Rhodmine B}-YGRKKRRQRRRCGIQDTNSKKQSDTHLEET-{Lys(pomalidomide-Suc-PEG2)}-NH2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (258 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shi YY, et al. Treating ICB-resistant cancer by inhibiting PD-L1 via DHHC3 degradation induced by cell penetrating peptide-induced chimera conjugates. Cell Death Dis. 2024 Sep 30;15(9):701. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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