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Cat. No.: HY-107572

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PD 128042

(Synonyms: CI 976)

1 Cited Publications

고객리뷰

Based on 1 publication(s) in Google Scholar

PD 128042 (CI 976) is a potent, orally active, and selective inhibitor of ACAT (acyl coenzyme A:cholesterol acyltransferase) with an IC₅₀s of 73 nM. PD 128042 is also a potent LPAT (lysophospholipid acyltransferase) inhibitor. PD 128042 inhibits Golgi-associated LPAT activity (IC₅₀=15 μM). PD 128042 inhibits multiple membrane trafficking steps, including ones found in the endocytic and secretory pathway.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity: 99.97%
CAS No.: 114289-47-3
화학식: C₂₃H₃₉NO₄
분자량:393.56

보관:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

PD 128042 Chemical Structure

CAS No.: 114289-47-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vivo
Chemical Information
Publications (1)
용액&용해도
- In Vitro
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Acyltransferase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Caco-2	IC₅₀	838 nM Compound: Cl-976	Compound was tested for inhibitory activity against ACAT from Caco-2 microsome in human Compound was tested for inhibitory activity against ACAT from Caco-2 microsome in human	[PMID: 10450977]
Huh-7	EC₅₀	0.6 μM Compound: CI-976	Induction of ABCA1 mRNA expression in human HuH7 cells after 24 hrs Induction of ABCA1 mRNA expression in human HuH7 cells after 24 hrs	[PMID: 23025824]
Peritoneal macrophage	IC₅₀	3.8 μM Compound: 4; CI-976	Inhibition of formation of foam cells in rat peritoneal macrophages Inhibition of formation of foam cells in rat peritoneal macrophages	[PMID: 36473091]

In Vivo

PD 128042 (CI 976) (10-30 mg/kg; gavage, in the chronic cholesterol-fed rat model) decreases non-high density lipoprotein (HDL)-cholesterol and increases HDL-cholesterol in rats with pre-established dyslipidemia^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 114289-47-3
Appearance Solid
분자량 393.56
화학식 C₂₃H₃₉NO₄
Color White to off-white
SMILES

CCCCCCCCCCC(C)(C)C(NC1=C(C=C(OC)C=C1OC)OC)=O
Synonyms

CI 976
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Aquat Toxicol

Is acyl-CoA cholesterol acyltransferase 2 the enzyme responsible for the esterification of okadaic acid in bivalves?. [Abstract]

2026 Jun:295:107814. PMID: 41935504

용액&용해도

In Vitro:

DMSO : 100 mg/mL (254.09 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.5409 mL

12.7045 mL

25.4091 mL

5 mM

0.5082 mL

2.5409 mL

5.0818 mL

10 mM

0.2541 mL

1.2705 mL

2.5409 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chambers K, et al. A unique lysophospholipid acyltransferase (LPAT) antagonist, CI-976, affects secretory and endocytic membrane trafficking pathways. J Cell Sci. 2005;118(Pt 14):3061-3071. [Content Brief]

[2]. O'Brien PM, et al. Inhibitors of acyl-CoA:cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 8. Incorporation of amide or amine functionalities into a series of disubstituted ureas and carbamates. Effects on ACAT inhibition in vitro and efficacy in vivo. J Med Chem. 1994;37(12):1810-1822. [Content Brief]

[3]. Drecktrah D, et al. Inhibition of a Golgi complex lysophospholipid acyltransferase induces membrane tubule formation and retrograde trafficking. Mol Biol Cell. 2003;14(8):3459-3469. [Content Brief]

[4]. Krause BR, et al. In vivo evidence that the lipid-regulating activity of the ACAT inhibitor CI-976 in rats is due to inhibition of both intestinal and liver ACAT. J Lipid Res. 1993;34(2):279-294. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.5409 mL	12.7045 mL	25.4091 mL	63.5227 mL
	5 mM	0.5082 mL	2.5409 mL	5.0818 mL	12.7045 mL
	10 mM	0.2541 mL	1.2705 mL	2.5409 mL	6.3523 mL
	15 mM	0.1694 mL	0.8470 mL	1.6939 mL	4.2348 mL
	20 mM	0.1270 mL	0.6352 mL	1.2705 mL	3.1761 mL
	25 mM	0.1016 mL	0.5082 mL	1.0164 mL	2.5409 mL
	30 mM	0.0847 mL	0.4235 mL	0.8470 mL	2.1174 mL
	40 mM	0.0635 mL	0.3176 mL	0.6352 mL	1.5881 mL
	50 mM	0.0508 mL	0.2541 mL	0.5082 mL	1.2705 mL
	60 mM	0.0423 mL	0.2117 mL	0.4235 mL	1.0587 mL
	80 mM	0.0318 mL	0.1588 mL	0.3176 mL	0.7940 mL
	100 mM	0.0254 mL	0.1270 mL	0.2541 mL	0.6352 mL

Keywords

PD 128042

1 Cited Publications

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PD 128042

Metabolism/Protease Compound Library

Clinical Compound Library

Drug Repurposing Compound Library

Orally Active Compound Library

Lipid Metabolism Compound Library

Human Metabolite Library

Metabolic Enzyme Compound Library

Highly Selective Inhibitors Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

Clinical Compound Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Publications Citing Use of MedChemExpress (MCE) PD 128042

All Acyltransferase Isoforms

Biological Activity

Chemical Information

Publications (1)

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

PD 128042

Metabolism/Protease Compound Library

Clinical Compound Library

Drug Repurposing Compound Library

Orally Active Compound Library

Lipid Metabolism Compound Library

Human Metabolite Library

Metabolic Enzyme Compound Library

Highly Selective Inhibitors Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

Clinical Compound Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Publications Citing Use of MedChemExpress (MCE) PD 128042

All Acyltransferase Isoforms

Biological Activity

Chemical Information

Publications (1)

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

PD 128042 Related Classifications

HY-107572 Related Classifications