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Cat. No.: HY-188175

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PDE-I2

PDE-I2 is a precursor small molecule of the naturally derived duocarmycin family that retains the sequence-specific DNA-binding property of this family but lacks the DNA-alkylating cyclopropyl warhead structure characteristic of this class of drugs. PDE-I2 inhibits the proliferation of blood-stage Plasmodium falciparum. PDE-I2 arrests Plasmodium falciparum development at the schizont stage, accompanied by defects in nuclear segregation, MTOC formation, IMC biogenesis, and plasma membrane invagination. PDE-I2 is useful for malaria-related research.

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CAS No.: 98296-23-2
화학식: C₂₅H₂₃N₅O₈
분자량:521.49

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

PDE-I2 Chemical Structure

CAS No.: 98296-23-2

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
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Biological Activity

제품 설명

All Parasite Isoforms :

All Endogenous Metabolite Isoforms :

In Vitro

Parasitic Infection

PDE-I2 is an inhibitor of P. falciparum proliferation and exhibits selectivity, with toxicity to human cell lines more than 1000-fold lower than that to P. falciparum^[1].
PDE-I2 blocks P. falciparum at the schizont stage, and treatment for 4 h induces malaria parasite DNA damage and impairs malaria parasite DNA replication, with its activity dependent on the active DNA replication process of P. falciparum^[1].
PDE-I2 does not affect the development of non-replicating gametocytes, but impairs DNA replication in gametocytes after activation; it causes severe defects in nuclear division, inner membrane complex biogenesis, and parasite plasma membrane formation in Plasmodium falciparum^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Cell Viability Determination by MTT Colorimetric Assay

Chemical Information

CAS No. 98296-23-2
분자량 521.49
화학식 C₂₅H₂₃N₅O₈
SMILES

O=C(O)C1=CC=2C(N1)=C(OC)C(O)=C3C2CCN3C(=O)C4=CC=5C(N4)=C(OC)C(O)=C6C5CCN6C(=O)N
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Alder A, et al. A non-reactive natural product precursor of the duocarmycin family has potent and selective antimalarial activity. Cell chemical biology. 2022 May 19;29(5):840-853.e6. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

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PDE-I2

All Parasite Isoforms

All Endogenous Metabolite Isoforms