Poloxin-2
Poloxin-2 is a small molecule Plk1 PBD inhibitor that can effectively induce cell mitotic arrest with an EC50 of approximately 15 μM in HeLa cells. Poloxin-2HT was developed by conjugating a hydrophobic tag (HT) to Poloxin-2, a new application of inhibitors targeting protein-protein interactions. Poloxin-2HT significantly enhanced the effects on cell viability and apoptosis by selectively degrading Plk1 protein, and its effect was stronger than that of untagged Poloxin-2. These data validate hydrophobic tags as a new strategy for targeting and disrupting disease-associated proteins.
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- CAS No.: 321695-37-8
- 화학식: C16H15NO3
- 분자량:269.30
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | EC50 |
15 μM
Compound: Poloxin-2
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Induction of mitotic arrest in human HeLa cells by propidium iodide staining-based FACS analysis
Induction of mitotic arrest in human HeLa cells by propidium iodide staining-based FACS analysis
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[PMID: 27425654] |
| HeLa | IC50 |
10.5 μM
Compound: Poloxin-2
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Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Antiproliferative activity against human HeLa cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
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[PMID: 37607438] |
Chemical Information
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CAS No. 321695-37-8
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분자량 269.30
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화학식 C16H15NO3
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SMILES
O=C(C(C)=C/1)C=C(C)C1=N/OC(C2=CC=CC=C2C)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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