Preclamol
Preclamol is a dopamine (DA) agonist with autoreceptor as well as postsynaptic receptor stimulatory properties. Preclamol inhibits the locomotor activity of mice and rats in low doses.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 85966-89-8
- 화학식: C14H21NO
- 분자량:219.32
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocol
- 순도&문서
- References
-
Help & FAQs
All Dopamine Receptor Isoforms
More
Biological Activity
제품 설명
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
163 nM
Compound: (-)-3PPP
|
Agonist activity at human D2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
Agonist activity at human D2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
|
[PMID: 26555041] |
| CHO | EC50 |
376 nM
Compound: (-)-3PPP
|
Antagonist activity against human D2 receptor expressed in CHO cells assessed as dopamine EC50 at 200 nM by [35S]GTPgammaS binding assay (Rvb = 225 +/- 45 nM)
Antagonist activity against human D2 receptor expressed in CHO cells assessed as dopamine EC50 at 200 nM by [35S]GTPgammaS binding assay (Rvb = 225 +/- 45 nM)
|
[PMID: 26555041] |
| CHO | EC50 |
51.9 nM
Compound: (-)-3PPP
|
Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
Agonist activity at human D3 receptor expressed in CHO cells by [35S]GTPgammaS binding assay
|
[PMID: 26555041] |
| CHO | EC50 |
844 nM
Compound: (-)-3PPP
|
Antagonist activity against human D2 receptor expressed in CHO cells assessed as dopamine EC50 at 1 uM by [35S]GTPgammaS binding assay (Rvb = 225 +/- 45 nM)
Antagonist activity against human D2 receptor expressed in CHO cells assessed as dopamine EC50 at 1 uM by [35S]GTPgammaS binding assay (Rvb = 225 +/- 45 nM)
|
[PMID: 26555041] |
Chemical Information
-
CAS No. 85966-89-8
-
분자량 219.32
-
화학식 C14H21NO
-
SMILES
CCCN1C[C@H](C2=CC(O)=CC=C2)CCC1
-
Synonyms
(-)-3-PPP
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
-
Protocol for Open Field Test (OF)
The Open Field Test is a rodent behavioral assay that measures spontaneous locomotion, exploratory behavior, and anxiety-like behavior when an animal is placed in a novel open arena. The main readouts are total distance traveled, movement time, velocity, center-zone entries, center-zone time, peripheral-zone time, and thigmotaxis. The assay is based on the conflict between exploration of a novel environment and avoidance of exposed open areas; higher center exploration is commonly interpreted as lower anxiety-like behavior, whereas increased wall-following or peripheral occupancy is interpreted as higher anxiety-like behavior.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Preclamol Related Classifications
HY-145454A Related Classifications
Powered by Bioz