IL-10
Interleukin-10 (IL-10) is the founding member of an anti-inflammatory cytokine family that includes IL-19, IL-20, IL-22, IL-24 and IL-26. This 18.5 kDa homodimeric cytokine is produced by nearly all immune cells, with regulatory T cells, Th1 cells, macrophages, dendritic cells and B cells being major sources. IL-10 engages a heterodimeric receptor (IL-10Rα/CD210 and IL-10Rβ) and signals through JAK1/TYK2-STAT3 to suppress pro-inflammatory cytokine (TNF, IL-1, IL-6, IL-12) production, downregulate MHC-II and co-stimulatory molecules on antigen-presenting cells, and inhibit macrophage and T-cell effector functions. This feedback restraint prevents immunopathology during infection, but is co-opted by tumors to achieve immune evasion; IL-10 pathway polymorphisms confer risk of inflammatory bowel disease and autoimmunity.
-
IL-10 Recombinant Proteins (16)
-
Inhibitors & Agonists (112)
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- Species:
- Source:
- 1
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 1
- 화학식: Human
- 분자량: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
