NAK
NAK kinases couple clathrin-mediated membrane traffic to signal transduction. The family contains AAK1, which binds the adaptor Numb and phosphorylates the AP-2 mu subunit to support cargo selection; GAK, the mammalian auxilin-related kinase that recruits Hsc70 to uncoat clathrin-coated vesicles; BMP2K, also called BIKE, implicated in BMP signaling and osteoblast differentiation; and STK16, a broadly expressed Golgi enzyme that sits on its own branch of the kinome. Because AAK1 and GAK control clathrin-dependent uptake, inhibitors of these kinases block entry of dengue, hepatitis C and other viruses in cell culture. GAK variants are additionally associated with Parkinson disease risk.
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NAK Recombinant Proteins (8)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- 화학식: Human
- 분자량: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
