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Cat. No.: HY-121706

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PU-20F

PU-20F is a Hsp90 inhibitor with an EC₅₀ of 6.8 μM. PU-20F competes with Geldanamycin (HY-15230) for binding to Hsp90 and regulates the function of this molecular chaperone. PU-20F induces the degradation of oncogenic Her2 tyrosine kinase. PU-20F blocks the growth of breast cancer cells. PU-20F can be used in breast cancer-related research.

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CAS No.: 422508-29-0
화학식: C₂₀H₂₄FN₅O₄
분자량:417.44

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

PU-20F Chemical Structure

CAS No.: 422508-29-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

HSP90

6.8 μM (EC₅₀)

All HSP Isoforms :

In Vitro

PU-20F (compound 59) competes with geldanamycin for binding to purified Hsp90 protein with an EC₅₀ of 6.8 μM^[1].
PU-20F (72 h) inhibits the growth of MCF-7 human breast cancer cells with an IC₅₀ of 23 μM^[1].
PU-20F induces degradation of Her2 tyrosine kinase in MCF-7 human breast cancer cells with an IC₅₀ of 20 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 422508-29-0
분자량 417.44
화학식 C₂₀H₂₄FN₅O₄
SMILES

FC=1N=C(N)C=2N=C(N(C2N1)CC3OCCC3)CC4=CC(OC)=C(OC)C(OC)=C4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Chiosis G, et al. Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase. Bioorg Med Chem. 2002;10(11):3555-3564. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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PU-20F

All HSP Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

PU-20F Related Classifications

HY-121706 Related Classifications