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Cat. No.: HY-183912

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PY-4Car2

PY-4Car2 is a Camptothecin (HY-16560) derivative and a topoisomerase I inhibitor. PY-4Car2 functions as a warhead conjugated via a cleavable linker to the bispecific ADC TJ101. PY-4Car2 can be used as an ADC payload for the research of cancers_.

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CAS No.: 3054643-04-5
화학식: C₂₉H₃₀FN₃O₇
분자량:551.56

보관:

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

PY-4Car2 Chemical Structure

CAS No.: 3054643-04-5

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수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

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Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Topoisomerase Isoforms :

All ADC Payloads Isoforms :

In Vitro

PY-4CAR2, when delivered via the bispecific dual-payload ADC TJ102 (co-formulated with PE-E2K), contributes to robust, selective cytotoxicity in ovarian and kidney cancer cell lines^[1].
PY-4Car2, as the warhead of bispecific ADC TJ101, drives synergistic cytotoxicity in EGFR- and B7-H3-coexpressing solid cancer cell lines, with activity dependent on target antigen binding^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3054643-04-5
Appearance Solid
분자량 551.56
화학식 C₂₉H₃₀FN₃O₇
Color White to light yellow
SMILES

OCCCCOC(N[C@@H]1C2=C3C(C(N4C3)=CC([C@](O)(C(OC5)=O)CC)=C5C4=O)=NC6=CC(F)=C(C)C(CC1)=C62)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

-20°C, sealed storage, away from moisture and light

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

순도&문서

Handling Instructions (2659 KB)

References

[1]. Yangxin Zhang, et al. Abstract LB021: TJ102: A promising bispecific dual-payload ADC targeting CDH6 and folate receptor alpha (FRα) for the treatment of ovarian and kidney cancers. Cancer Res (2025) 85 (8_Supplement_2): LB021.

[2]. Li Qi, et al. Abstract 2955: Preclinical development of TJ101, a potent bispecific ADC targeting EGFR and B7-H3 for the treatment of solid cancers. Cancer Res (2025) 85 (8_Supplement_1): 2955.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

상품명:
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PY-4Car2

All Topoisomerase Isoforms

All ADC Payloads Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

PY-4Car2 Related Classifications

HY-183912 Related Classifications