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Cat. No.: HY-W746425

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Rapamycin dialdehyde

Rapamycin dialdehyde is a non-immunosuppressive macrolide dialdehyde that promotes neuronal regeneration and functional recovery by inducing neurite outgrowth, and inhibits solid tumor cell growth and hyperproliferative vascular diseases. Rapamycin dialdehyde is used in the research of neurodegenerative diseases and cancer.

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CAS No.: 500733-49-3
화학식: C₅₁H₇₉NO₁₅
분자량:946.17

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Rapamycin dialdehyde Chemical Structure

CAS No.: 500733-49-3

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
3T3	IC50	0.72 μg/mL	Antineoplastic activity against mouse 3T3 ovarian tumor cells assessed as inhibition of cell growth incubated for 48 hrs by sulforhodamine B colorimetric assay. Antineoplastic activity against mouse 3T3 ovarian tumor cells assessed as inhibition of cell growth incubated for 48 hrs by sulforhodamine B colorimetric assay.	en?oq=WO+03%2f018574+Al
3T3	IC50	0.68 μg/mL	Antineoplastic activity against mouse 3T3/H2N ovarian tumor cells resistant to cis-platin assessed as inhibition of cell growth incubated for 48 hrs by sulforhodamine B colorimetric assay. Antineoplastic activity against mouse 3T3/H2N ovarian tumor cells resistant to cis-platin assessed as inhibition of cell growth incubated for 48 hrs by sulforhodamine B colorimetric assay.	en?oq=WO+03%2f018574+Al
A-431	IC50	0.91 μg/mL	Antineoplastic activity against human A431 vulva epidermoid tumor cells assessed as inhibition of cell growth incubated for 48 hrs by sulforhodamine B colorimetric assay. Antineoplastic activity against human A431 vulva epidermoid tumor cells assessed as inhibition of cell growth incubated for 48 hrs by sulforhodamine B colorimetric assay.	en?oq=WO+03%2f018574+Al
SK-BR-3	IC50	0.52 μg/mL	Antineoplastic activity against human SKBR3 breast tumor cells assessed as inhibition of cell growth incubated for 48 hrs by sulforhodamine B colorimetric assay. Antineoplastic activity against human SKBR3 breast tumor cells assessed as inhibition of cell growth incubated for 48 hrs by sulforhodamine B colorimetric assay.	en?oq=WO+03%2f018574+Al
MDA-MB-435	IC50	1.23 μg/mL	Antineoplastic activity against human MDA-435 breast tumor cells assessed as inhibition of cell growth incubated for 48 hrs by sulforhodamine B colorimetric assay. Antineoplastic activity against human MDA-435 breast tumor cells assessed as inhibition of cell growth incubated for 48 hrs by sulforhodamine B colorimetric assay.	en?oq=WO+03%2f018574+Al
SW-620	IC50	1.41 μg/mL	Antineoplastic activity against human SW620 colon tumor cells assessed as inhibition of cell growth incubated for 48 hrs by sulforhodamine B colorimetric assay. Antineoplastic activity against human SW620 colon tumor cells assessed as inhibition of cell growth incubated for 48 hrs by sulforhodamine B colorimetric assay.	en?oq=WO+03%2f018574+Al

In Vitro

Anti-cancerOthers

Anti-cancer

Rapamycin dialdehyde (48 h) exhibits antineoplastic activity against various solid tumor cell lines, including 3T3, 3T3/H2N, A431, SKBR3, MDA-435, and SW620, with IC₅₀ values ranging from 0.52 to 1.41 μg/mL^[1].

Others

Rapamycin dialdehyde (168 h) promotes neurite outgrowth in SH-SY5Y cells, demonstrating neurotrophic activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 500733-49-3
분자량 946.17
화학식 C₅₁H₇₉NO₁₅
SMILES

O=C([C@@]1(O[C@@H](CC[C@H]1C)C[C@H](OC)/C(C)=C/C=O)O)C(N2[C@@H](CCCC2)C(O[C@@H](CC([C@H](C)/C=C(C)/[C@@H](O)[C@@H](OC)C([C@H](C)C[C@H](C)/C=C/C=O)=O)=O)[C@H](C)C[C@H]3C[C@H]([C@@H](CC3)O)OC)=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Zhu T, et al. Rapamycin dialdehydes. WO2003018574A1. WIPO(PCT). 2003.

[2]. Inayat-Hussain, et al. Recent advances in the discovery and development of stilbenes and lactones in anticancer therapy. Expert Opinion on Therapeutic Patents, 14(6), 819-835.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

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Rapamycin dialdehyde