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United States

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Cat. No.: HY-124261

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Sampangine

Sampangine is an alkaloid that induces apoptosis by inducing cell cycle arrest in the G0/G1 phase. Sampangine can inhibit the biosynthesis of heme.

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CAS No.: 116664-93-8
화학식: C₁₅H₈N₂O
분자량:232.24

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Sampangine Chemical Structure

CAS No.: 116664-93-8

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Sampangine is an alkaloid that induces apoptosis by inducing cell cycle arrest in the G0/G1 phase. Sampangine can inhibit the biosynthesis of heme^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	0.6 μM Compound: 6	Antiproliferative activity against human A2780 cells after 2 days by Alamar Blue assay Antiproliferative activity against human A2780 cells after 2 days by Alamar Blue assay	[PMID: 21504145]
BT-549	IC₅₀	6.4 μg/mL Compound: 4	Cytotoxicity against human BT549 cells after 2 to 7 days by neutral red assay Cytotoxicity against human BT549 cells after 2 to 7 days by neutral red assay	[PMID: 11374943]
HeLa	IC₅₀	>10 μg/mL Compound: 4	Inhibition of LFA1/ICAM1-mediated CFSE-labeled TPA-stimulated human HL60 cell adhesion to ICAM1 expressing human HeLa cells after 45 mins by fluorescence analysis Inhibition of LFA1/ICAM1-mediated CFSE-labeled TPA-stimulated human HL60 cell adhesion to ICAM1 expressing human HeLa cells after 45 mins by fluorescence analysis	[PMID: 11374943]
HL-60	IC₅₀	2 μg/mL Compound: 4	Cytotoxicity against human HL60 cells after 7 days by XTT/PMS assay Cytotoxicity against human HL60 cells after 7 days by XTT/PMS assay	[PMID: 11374943]
KB	IC₅₀	5.3 μg/mL Compound: 4	Cytotoxicity against human KB cells after 2 to 7 days by neutral red assay Cytotoxicity against human KB cells after 2 to 7 days by neutral red assay	[PMID: 11374943]
NCI-H460	IC₅₀	0.58 μM Compound: 6	Antiproliferative activity against human H460 cells after 96 hrs by Cell Titre-Glo luminescent assay Antiproliferative activity against human H460 cells after 96 hrs by Cell Titre-Glo luminescent assay	[PMID: 21504145]
SK-MEL	IC₅₀	0.37 μg/mL Compound: 4	Cytotoxicity against human SK-MEL cells after 2 to 7 days by neutral red assay Cytotoxicity against human SK-MEL cells after 2 to 7 days by neutral red assay	[PMID: 11374943]
SK-OV-3	IC₅₀	4.1 μg/mL Compound: 4	Cytotoxicity against human SKOV3 cells after 2 to 7 days by neutral red assay Cytotoxicity against human SKOV3 cells after 2 to 7 days by neutral red assay	[PMID: 11374943]

Chemical Information

CAS No. 116664-93-8
분자량 232.24
화학식 C₁₅H₈N₂O
SMILES

O=C1C2=NC=CC3=CC=NC(C4=C1C=CC=C4)=C32
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Pérez EG, et al. Alkaloids from the genus Duguetia. Alkaloids Chem Biol. 2010;68:83-156. [Content Brief]

[2]. Huang Z, et al. Sampangine inhibits heme biosynthesis in both yeast and human. Eukaryot Cell. 2011 Nov;10(11):1536-44. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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