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Cat. No.: HY-169728

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SID 24785302

SID 24785302 is a hexokinase inhibitor with antiparasitic activity. SID 24785302 exhibits activity against T. brucei and Leishmania. SID 24785302 can be used for the research of mitochondrial DNA disorders and parasitic infection.

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CAS No.: 378197-09-2
화학식: C₁₄H₁₂N₂O₃S₂
분자량:320.39

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

SID 24785302 Chemical Structure

CAS No.: 378197-09-2

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Parasite Isoforms :

In Vitro

SID 24785302 (10 μM; 2 h) potently and selectively inhibits bacterially expressed Trypanosoma brucei hexokinase 1 with an IC₅₀ of 4.2 μM, while causing minimal inhibition of human glucokinase at 10 μM^[3].
SID 24785302 (3 days) potently inhibits the growth of Trypanosoma brucei bloodstream form parasites with an EC₅₀ of 0.042 μM^[3].
SID 24785302 (10 μM; 2 days) moderately inhibits the growth of Trypanosoma brucei procyclic form parasites, causing 47% inhibition at 10 μM^[3].
SID 24785302 (44 h) inhibits the growth of Leishmania major promastigotes with an EC₅₀ of 1.9 μM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 378197-09-2
분자량 320.39
화학식 C₁₄H₁₂N₂O₃S₂
SMILES

O=C(CC1=CSC(N2SC3=C(C2=O)C=CC=C3)=N1)OCC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Antonella SPINAZZOLA, et al. Compounds for treating mitochondrial dna disorders. WO2023089313A1.

[2]. Heneberg P. Redox Regulation of Hexokinases. Antioxid Redox Signal. 2019 Jan 20;30(3):415-442. [Content Brief]

[3]. Sharlow ER, et al. A target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activity. PLoS Negl Trop Dis. 2010;4(4):e659. Published 2010 Apr 13. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

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SID 24785302

All Parasite Isoforms