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Sintilimab

(Synonyms: IBI308)
3 Cited Publications
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Based on 3 publication(s) in Google Scholar

Sintilimab (IBI308) is a safe and effectivel humanized IgG4 monoclonal antibody that binds to PD-1 with a KD value of 74 pM. Sintilimab blocks the interaction of PD-1 with its ligands (PD-L1 and PL-L2), consequently helping to restore the endogenous antitumour T-cell response. Sintilimab combined with prebiotics inhibits tumor volume and regulates immune cell subpopulation balance in lung adenocarcinoma mice. Sintilimab can be used for the research of classical Hodgkin's lymphoma, non-small cell lung cancer and oesophageal cancer.

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  • Experimental Validation Results for Sintilimab
  • Experimental Validation Results for Sintilimab
  • Experimental Validation Results for Sintilimab
  • Sintilimab Chemical Structure
    Sintilimab Chemical Structure
CAS No.: 2072873-06-2
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Assay Types
  • 1/16

    Human IgG4 kappa

  • 1/16

    Immobilized PD-1 Protein, Human (143a.a, HEK293, His, HY-P7396) can bind Sintilimab. The EC50 for this effect is 6.653 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 10 ng/mL PMA and 1 μg/mL Ionomycin co-stimulated Jurkat cells(24h) labeling Sintilimab (HY-P99048, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Sintilimab Chemical Structure
    1/16
  • Sintilimab
  • Immobilized PD-1 Protein, Human (143a.a, HEK293, His, HY-P7396) can bind Sintilimab. The EC50 for this effect is 6.653 ng/mL.
  • Flow cytometric analysis of 1X106 10 ng/mL PMA and 1 μg/mL Ionomycin co-stimulated Jurkat cells(24h) labeling Sintilimab (HY-P99048, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Fluor 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).