SJ-3366
SJ-3366 (IQP-0410) is a potent inhibitor of HIV nonnucleoside reverse transcriptase. SJ-3366 (IQP-0410) inhibits HIV at sub-nanomolar concentrations primarily through a typical non-nucleoside mechanism.
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- CAS No.: 195720-26-4
- 화학식: C21H24N2O3
- 분자량:352.43
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
nonnucleoside reverse transcriptase[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CEM-SS | EC50 |
0.002 μM
Compound: 62, SJ-3386
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Antiviral activity against HIV1 RF infected in human CEM-SS cells assessed as inhibition of virus-induced cytopathic effect by XTT assay
Antiviral activity against HIV1 RF infected in human CEM-SS cells assessed as inhibition of virus-induced cytopathic effect by XTT assay
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[PMID: 17967909] |
| CEM-SS | EC50 |
16 μM
Compound: 62, SJ-3386
|
Antiviral activity against HIV2 ROD infected in human CEM-SS cells assessed as inhibition of virus-induced cytopathic effect by XTT assay
Antiviral activity against HIV2 ROD infected in human CEM-SS cells assessed as inhibition of virus-induced cytopathic effect by XTT assay
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[PMID: 17967909] |
| HeLa | EC50 |
0.07 μM
Compound: 62, SJ-3386
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Antiviral activity against HIV1 infected in human HeLa cells expressing CD4-LTR assessed as inhibition of viral entry-related beta galactosidase expression treated for 2 hrs followed by drug wash out measured after 48 hrs by MAGI assay
Antiviral activity against HIV1 infected in human HeLa cells expressing CD4-LTR assessed as inhibition of viral entry-related beta galactosidase expression treated for 2 hrs followed by drug wash out measured after 48 hrs by MAGI assay
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[PMID: 17967909] |
Chemical Information
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CAS No. 195720-26-4
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분자량 352.43
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화학식 C21H24N2O3
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SMILES
O=C1NC(C(CC)=C(N1CC2CC=CC2)C(C3=CC(C)=CC(C)=C3)=O)=O
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Synonyms
IQP-0410
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Ham AS, Lustig W, Yang L, Boczar A, Buckheit KW, Buckheit RW Jr. In vitro and ex vivo evaluations on transdermal delivery of the HIV inhibitor IQP-0410. PLoS One. 2013;8(9):e75306. [Content Brief]
[2]. Buckheit RW Jr, Watson Buckheit K, Sturdevant CB, Buckheit RW 3rd. Selection and characterization of viruses resistant to the dual acting pyrimidinedione entry and non-nucleoside reverse transcriptase inhibitor IQP-0410. Antiviral Res. 2013;100(2):382-391 [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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