Sulfonadyn-47
Sulfonadyn-47 is a GTP-competitive dynamin I (dynI) inhibitor that targets the active site in the GTPase domain of dynamin I, with IC50 values of 3.5 μM against dynI, 27.3 μM in clathrin-mediated endocytosis (CME) assays, and 12.3 μM in synaptic vesicle endocytosis (SVE) assays. Sulfonadyn-47 increases seizure threshold. Sulfonadyn-47 can be used the study for the seizure.
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- CAS No.: 3064686-59-2
- 화학식: C22H23BrN2O2S
- 분자량:459.40
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
In Vitro
Sulfonadyn-47 shows inhibitory activity against dynI with IC50 values of 3.5 μM for dynI, 27.3 μM in clathrin-mediated endocytosis (CME) assays, and 12.3 μM in synaptic vesicle endocytosis (SVE) assays[1].
Sulfonadyn-47 (80 μM) has no effect on glutamate release in the synaptosomes [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Valproate induced 6 Hz acute seizures mouse model
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Dosage:10, 30, 60 mg/kg
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Administration:i.p. 30 min before stimulation
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Result:Increased seizure threshold at doses of 30 and 60 mg/kg dose-dependently, with the threshold for the 60 mg/kg dose being equivalent to that to induce seizures in 50% of mice given 400 mg/kg of valproate.
Chemical Information
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CAS No. 3064686-59-2
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분자량 459.40
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화학식 C22H23BrN2O2S
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SMILES
BrC1=CC=C(C=C1)/C=C/CNCCCNS(=O)(C2=C3C=CC=CC3=CC=C2)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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