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Cat. No.: HY-120867

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TASP0376377

TASP0376377 is a potent and selective CRTH2 antagonist (IC₅₀: 13 nM). TASP0376377 has binding affinity for CRTH2 (IC₅₀: 19 nM).

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CAS No.: 1233246-60-0
화학식: C₂₅H₁₆Cl₂N₂O₄
분자량:479.31

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

TASP0376377 Chemical Structure

CAS No.: 1233246-60-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

TASP0376377 is a potent and selective CRTH2 antagonist (IC₅₀: 13 nM). TASP0376377 has binding affinity for CRTH2 (IC₅₀: 19 nM)^[1].

All Prostaglandin Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	19 nM Compound: 15-20, TASP0376377	Displacement of [3H]PGD2 from human CRTH2 transfected in CHO cells by liquid scintillation counting analysis Displacement of [3H]PGD2 from human CRTH2 transfected in CHO cells by liquid scintillation counting analysis	[PMID: 24216094]
CHO	IC₅₀	19 nM Compound: 6m, TASP0376377	Displacement of 3H-PGD2 from human CRTH2 receptor expressed in CHO cells Displacement of 3H-PGD2 from human CRTH2 receptor expressed in CHO cells	[PMID: 22469703]

Chemical Information

CAS No. 1233246-60-0
분자량 479.31
화학식 C₂₅H₁₆Cl₂N₂O₄
SMILES

O=C(NC1=CC=C(C=C1)C(C2=NC=C(C3=C2C=CC=C3)CC(O)=O)=O)C4=CC=C(C(Cl)=C4)Cl
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Nishikawa-Shimono R, et al. Isoquinoline derivatives as potent CRTH2 antagonists: design, synthesis and SAR. Bioorg Med Chem. 2013 Dec 15;21(24):7674-85. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
Chemical Information
순도&문서
References

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TASP0376377

All Prostaglandin Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

TASP0376377 Related Classifications

HY-120867 Related Classifications