TCS 2510
Based on 1 Customer Validation
TCS 2510 is a selective EP4 agonist. TCS 2510 can be used for the research of metabolic diseases.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 98.30%
- CAS No.: 346673-06-1
- 화학식: C21H29N5O2
- 분자량:383.49
-
보관:
Solution, -20°C, 2 years
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
Biological Activity
EP4[1]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
2.5 nM
Compound: 19a
|
EP4 agonist potency utilizing a stable clone of pSV40-EP4 transfected into HEK293 cells expressing EP4 receptor
EP4 agonist potency utilizing a stable clone of pSV40-EP4 transfected into HEK293 cells expressing EP4 receptor
|
[PMID: 12643927] |
| HEK293 | IC50 |
1.4 nM
Compound: 19a
|
Inhibitory activity against human EP4 receptor expressed in HEK293 ebna cells
Inhibitory activity against human EP4 receptor expressed in HEK293 ebna cells
|
[PMID: 12643927] |
TCS 2510 (0.001~100 μM; GLUTag cells) stimulates glucagon like peptide 1 secretion. TCS2510 activates the Gas signaling pathway. TCS 2510 (10 μM; 2~24 h; GLUTag cells) increases the Gcg mRNA expression levels. TCS 2510 produces a concentration dependent increase in cAMP levels in GLUTag cells with EC50 of 20 nM and the maximal stimulation of 60 % over the basal cAMP levels. The decrease in cell impedance in GLUTag cells observed with TCS 2510 is concentration dependent with IC50 of 15 nM. TCS 2510 produces a concentration-dependent increase in glucagon like peptide 2 secretion in GLUTag cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
TCS 2510 (10 mg/kg; p.o.) increases plasma glucagon like peptide 1 levels up to 8-fold over the basal hormone levels[1].
TCS 2510 (1~10 mg/kg; p.o) affords a significant elevation in plasma glucagon like peptide 2 levels[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Mice[1]
-
Dosage:0.1~10 mg/kg
-
Administration:P.o.
-
Result:Produced a dose-dependent elevation in plasma glucagon like peptide 1 levels in fasted mice measured 15 min after compound administration.
-
Animal Model:Mice[1]
-
Dosage:10 mg/kg
-
Administration:P.o.
-
Result:Increased plasma glucagon like peptide 1 levels up to 8-fold over the basal hormone levels.
-
Animal Model:Mice[1]
-
Dosage:1~10 mg/kg
-
Administration:P.o.
-
Result:Afforded a significant elevation in plasma glucagon like peptide 2 levels.
Chemical Information
-
CAS No. 346673-06-1
-
Appearance Liquid
-
분자량 383.49
-
화학식 C21H29N5O2
-
Color Colorless to light yellow
-
SMILES
O=C1N(CCCCCCC2=NNN=N2)[C@@H](/C=C/[C@@H](O)CC3=CC=CC=C3)CC1
-
Synonyms
CAY10598
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Solution, -20°C, 2 years
순도&문서
-
Data Sheet (275 KB)
-
SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TCS 2510 Related Classifications
HY-108557 Related Classifications
Powered by Bioz