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Cat. No.: HY-18970

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TG6-129

TG6-129 is a selective antagonist of the EP₂ receptor. TG6-129 reduces the expression of inflammatory factors induced by butaprost in P388D1 macrophages.

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CAS No.: 1164464-14-5
화학식: C₂₀H₁₈FN₅O₃S₃
분자량:491.58

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

TG6-129 Chemical Structure

CAS No.: 1164464-14-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

TG6-129 is a selective antagonist of the EP₂ receptor. TG6-129 reduces the expression of inflammatory factors induced by butaprost in P388D1 macrophages^[1].

IC₅₀ & Target

All Prostaglandin Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
C6	CC₅₀	326 μM Compound: 1, TG6-129, 17503974	Cytotoxicity against rat C6 cells after 48 hrs Cytotoxicity against rat C6 cells after 48 hrs	[PMID: 23914286]
C6	IC₅₀	1.6 μM Compound: 1, TG6-129, 17503974	Antagonist activity at human EP2 receptor overexpressed in rat C6 cells assessed as inhibition of PGE2-induced cAMP accumulation incubated for 10 mins prior to PGE2 addition measured after 40 mins by TR-FRET assay Antagonist activity at human EP2 receptor overexpressed in rat C6 cells assessed as inhibition of PGE2-induced cAMP accumulation incubated for 10 mins prior to PGE2 addition measured after 40 mins by TR-FRET assay	[PMID: 23914286]

Chemical Information

CAS No. 1164464-14-5
분자량 491.58
화학식 C₂₀H₁₈FN₅O₃S₃
SMILES

O=C(NC(NC1=CC=C(S(=O)(NC2=NN=C(CC)S2)=O)C=C1)=S)/C=C/C3=CC=C(F)C=C3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ganesh T, et al. Discovery and characterization of carbamothioylacrylamides as EP2 selective antagonists. ACS Med Chem Lett. 2013 Jul 11;4(7):616-621. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

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Concentration _(start) Concentration _(start)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
순도&문서
References

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TG6-129

All Prostaglandin Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

TG6-129 Related Classifications

HY-18970 Related Classifications