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Cat. No.: HY-179132

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TN-101

TN-101 is an orally active NLRP3 inhibitor (IC₅₀ = 29.8 nM). TN-101 can be used for the study of obesity.

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화학식: C₁₈H₂₀FIN₂O₃
분자량:458.27

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (244 KB)

TN-101 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

TN-101 is an orally active NLRP3 inhibitor (IC₅₀ = 29.8 nM). TN-101 can be used for the study of obesity^[1].

IC₅₀ & Target

NLRP3

29.8 nM (IC₅₀)

All NOD-like Receptor (NLR) Isoforms :

In Vitro

TN-101 (2 h) can effectively inhibit the secretion of IL-1β (IC₅₀ = 5.58 nM) by THP-1 cells, under Lipopolysaccharides (HY-D1056) (LPS)/Nigericin (HY-127019) stimulation^[1].
TN-101 (0.3 nM-6 μM, 1 h) can dose-dependently inhibit the secretion of IL-1β (IC₅₀ = 5.97 nM) and IL-18 (IC₅₀ = 12.2 nM) in THP-1 cells induced by Palmitic acid (HY-N0830)-BSA complex^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

TN-101 (1-10 mg/kg, p.o., twice daily, 15-28 days) does not affect the body weight of Diet-induced obese (DIO) mice, indicating that only NLRP3 inhibitors that can enter the central nervous system and reach effective doses can induce sustained weight loss in DIO mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Diet-induced obese (DIO) and Normal chow (NC)-fed lean mice^[1].
Dosage:

1 mg/kg, 3 mg/kg, 10 mg/kg
Administration:

P.o., twice daily for 15 days
Result:

Showed no effect on the weight of DIO and NC lean mice.

Animal Model:

Diet-induced obese (DIO) and Normal chow (NC)-fed lean mice^[1].
Dosage:

1 mg/kg
Administration:

P.o., twice daily for 28 days
Result:

Showed no effect on the weight of DIO and NC lean mice.

Chemical Information

분자량 458.27
화학식 C₁₈H₂₀FIN₂O₃
SMILES

O[C@]1(C[C@H](C1)NC(CN2C[C@@]3(C4=C(C2=O)C=CC(I)=C4)C[C@H]3F)=O)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (244 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

TN-101

All NOD-like Receptor (NLR) Isoforms

Biological Activity

제품 설명

IC50 & Target

In Vitro

In Vivo

Chemical Information

순도&문서

Calculators

Help & FAQs

TN-101 Related Classifications

HY-179132 Related Classifications

Bioz

Keywords

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