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Cat. No.: HY-184593

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UM-232

UM-232 is a highly selective covalent STING antagonist with an EC₅₀ of 6.20 μM in STING R232-expressing THP-1 cells. UM-232 covalently targets C292 and C309 cysteines of STING, blocks STING oligomerization and inhibits downstream TBK1/IRF3 activation and proinflammatory cytokine transcription. UM-232 has low off-target reactivity and good hepatic stability, serving as a chemical probe for STING-driven autoimmune and inflammatory diseases including Aicardi-Goutières syndrome (AGS), Systemic Lupus Erythematosus (SLE) and Amyotrophic Lateral Sclerosis (ALS).

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화학식: C₂₉H₃₅ClN₆O₂
분자량:535.08

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

UM-232 Chemical Structure

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

UM-232 (1 h) exhibits minimal toxicity at concentrations below 40 μM in THP1 Dual cells^[1].
UM-232 covalently engages C292 and C309 residues of STING in HEK293T cells^[1].
UM-232 (2.5-5 μM; 1 h) inhibits diABZI (diABZI STING agonist-1) (HY-112921A)-triggered transcription of Ifnb, Il6, and Cxcl10 in a dose-dependent manner in BMDMs^[1].
UM-232 (5 μM; 1 h) inhibits STING activation and downstream signaling in vitro in BMDMs^[1].
UM-232 (5 μM; 15 min) possesses favorable metabolic stability in human liver microsomes and superior stability relative to control compound in mouse liver microsomes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HEK293T cells
Concentration:

5 μM
Incubation Time:

1 h
Result:

Covalently bound wild-type STING.
Produced drastically weakened labeling signals on STING with C292A or C309 mutations.
Markedly reduced the levels of phospho-IRF3 and phospho-TBK1 after treatment.
Blocked STING oligomerization.

RT-PCR^[1]

Cell Line:

Bone marrow-derived macrophages (BMDMs)
Concentration:

2.5 μM, 5 μM
Incubation Time:

1 h
Result:

Suppressed diABZI-induced transcription of Ifnb, Il6, and Cxcl10 in a dose-dependent manner.

Chemical Information

분자량 535.08
화학식 C₂₉H₃₅ClN₆O₂
SMILES

CC(Cl)C(NCCC[C@H](N1N=NC(C2=CC=C(C3=CC=CC=C3)C=C2)=C1)C(N(CC4)CCC54COC5)=O)=N
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Barasa L, et al. The Development of UM-232, a Covalent STING Antagonist. ACS Med Chem Lett. 2026;17:1547-1554.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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