UNC8212
UNC8212 is a TAM kinase inhibitor. UNC8212 has potent inhibitory activity against MERTK and AXL (IC50: 1.5 nM and 1.3 nM, respectively), and also inhibits TYRO3 (IC50: 6.7 nM). UNC8212 mediates polypharmacological properties by targeting the structurally diverse "back pocket" region of the TAM kinase family. UNC8212 binds tightly to TAM kinases and potently inhibits MERTK and AXL phosphorylation. UNC8212 has anti-tumor effects and can be used in cancer immunotherapy and tumor cell targeting research.
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- 화학식: C34H42N8O3
- 분자량:610.75
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Axl 1.3 nM (IC50) |
MERTK 1.5 nM (IC50) |
Tyro3 6.7 nM (IC50) |
Chemical Information
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분자량 610.75
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화학식 C34H42N8O3
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SMILES
CC(C)C(NC1=CC(C#CC2=CC=C(NC3=NC(N[C@@H]4CC[C@@H](O)CC4)=C(C(NC5CCN(C)CC5)=O)C=N3)C=C2)=NC=C1)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
UNC8212 Related Classifications
HY-173400 Related Classifications
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