country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-119161

Copy Link Print Information

VX-759

Name: VX-759
Brand: MedChemExpress
SKU: HY-119161
Availability: PreOrder

(Synonyms: VCH-759)

VX-759 (VCH-759) is an orally active HCV NS5B RNA-dependent RNA polymerase inhibitor. VX-759 is promising for research of chronic hepatitis C.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 478025-29-5
화학식: C₂₂H₂₇NO₃S
분자량:385.52

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

VX-759 Chemical Structure

CAS No.: 478025-29-5

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- Clinical Trial
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

VX-759 (VCH-759) is an orally active HCV NS5B RNA-dependent RNA polymerase inhibitor. VX-759 is promising for research of chronic hepatitis C^[1].

IC₅₀ & Target

RNA Polymerase

All DNA/RNA Synthesis Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	CC₅₀	>50000 nM Compound: 21	Cytotoxicity against human HuH7 cells by MTT assay Cytotoxicity against human HuH7 cells by MTT assay	[PMID: 19877603]
Huh-7	CC₅₀	>=20 μM Compound: 9	Cytotoxicity against human HuH7 cells after 3 days by Cell Titre Glo assay Cytotoxicity against human HuH7 cells after 3 days by Cell Titre Glo assay	[PMID: 24144213]
Huh-7	CC₅₀	48 μM Compound: 2	Cytotoxicity against human HuH7 cells by WST-1 assay Cytotoxicity against human HuH7 cells by WST-1 assay	[PMID: 20584604]
Huh-7	EC₅₀	0.23 μM Compound: 2	Antiviral activity against HSV Con1 GT1b infected in HuH7 cells by replicon assay Antiviral activity against HSV Con1 GT1b infected in HuH7 cells by replicon assay	[PMID: 20584604]
Huh-7	EC₅₀	1400 nM Compound: 21	Antiviral activity against HCV1b Con1 infected in human Huh7 clone HBI10A cells expressing HEPREP 1b replicon by cell-ELISA assay Antiviral activity against HCV1b Con1 infected in human Huh7 clone HBI10A cells expressing HEPREP 1b replicon by cell-ELISA assay	[PMID: 19877603]
Huh-7	EC₅₀	170 nM Compound: 9	Antiviral activity against Hepatitis C virus H77 genotype 1a infected in human HuH7 cells assessed as intrinsic antiviral potency after 72 hrs by luciferase reporter gene assay Antiviral activity against Hepatitis C virus H77 genotype 1a infected in human HuH7 cells assessed as intrinsic antiviral potency after 72 hrs by luciferase reporter gene assay	[PMID: 24144213]
Huh-7	EC₅₀	2100 nM Compound: 9	Antiviral activity against Hepatitis C virus H77 genotype 1a infected in human HuH7 cells assessed as observed antiviral potency after 72 hrs by luciferase reporter gene assay Antiviral activity against Hepatitis C virus H77 genotype 1a infected in human HuH7 cells assessed as observed antiviral potency after 72 hrs by luciferase reporter gene assay	[PMID: 24144213]
Huh-7	EC₅₀	593 nM Compound: 9	Antiviral activity against Hepatitis C virus Con1 genotype 1b infected in human HuH7 cells after 72 hrs by luciferase reporter gene assay Antiviral activity against Hepatitis C virus Con1 genotype 1b infected in human HuH7 cells after 72 hrs by luciferase reporter gene assay	[PMID: 24144213]
MT4	CC₅₀	>20 μM Compound: 9	Cytotoxicity against human MT4 cells after 5 days by Cell Titre Glo assay Cytotoxicity against human MT4 cells after 5 days by Cell Titre Glo assay	[PMID: 24144213]

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 478025-29-5
분자량 385.52
화학식 C₂₂H₂₇NO₃S
SMILES

O=C([C@@H]1CC[C@H](CC1)C)N(C2=C(SC(C3=CC=CC=C3)=C2)C(O)=O)C(C)C
Synonyms

VCH-759
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cooper C, et al. Evaluation of VCH-759 monotherapy in hepatitis C infection. J Hepatol. 2009 Jul;51(1):39-46. doi: 10.1016/j.jhep.2009.03.015. Epub 2009 Apr 23. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기