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Cat. No.: HY-163315

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YPLP

YPLP is a yeast-derived peptide Tyr-Pro-Leu-Pro, which exhibits activity in anti fatigue mechanisms through the nuclear factor erythroid-2-related factor 2 (Nrf2)- and AMP-activated protein kinase (AMPK) pathway. YPLP is orally active.

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CAS No.: 2414391-44-7
화학식: C₂₅H₃₆N₄O₆
분자량:488.58

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

YPLP Chemical Structure

CAS No.: 2414391-44-7

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

All AMPK Isoforms :

In Vivo

YPLP (10-50 mg/kg, i.g. for 4 weeks) alleviates exhaustive exercise caused oxidative damage by decreasing lipid oxidation and increasing antioxidant enzyme activities in muscle tissues through Nrf2/Keap1 pathway^[1].
YPLP (10-50 mg/kg, i.g. for 4 weeks) improves ATP levels and energy metabolism through phosphorylation of AMPK and promotion of AMPK proteins in fatigue ICR mice^[1].
YPLP (10-50 mg/kg, i.g. for 4 weeks) regulates expressions of differential abundance proteins (DAPs), participates in the protein biosynthesis/degradation, muscle dynamics, and nuclear transport process to regulate muscle function in fatigue mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ICR mice^[1]
Dosage:

10-50 mg/kg/d
Administration:

i.g. for 4 weeks
Result:

Increased levels of Nrf2, ATP, pAMPK and decreased levels of Keap1.

Chemical Information

CAS No. 2414391-44-7
분자량 488.58
화학식 C₂₅H₃₆N₄O₆
Sequence

Tyr-Pro-Leu-Pro
Sequence Shortening

YPLP
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cai J, et al., Studying Antifatigue Mechanism of Tyr-Pro-Leu-Pro in Exercise Mice Using Label-Free Proteomics. J Agric Food Chem. 2024 Jan 31;72(4):2178-2192. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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