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Cat. No.: HY-181117

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YTH-IN-2

YTH-IN-2 is a YTH domain inhibitor of YTHDC2 with an IC₅₀ of 16.84 μM. YTH-IN-2 can serve as a lead compound for discovering efficient, selective, and cell-active small-molecule inhibitors of YTHDC2.

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CAS No.: 86886-76-2
화학식: C₁₄H₁₂ClNO₂
분자량:261.70

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

YTH-IN-2 Chemical Structure

CAS No.: 86886-76-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

YTHDC2

16.84 μM (IC₅₀)

All YTHDF Isoforms :

In Vitro

YTH-IN-2 (H3) (30 min compound-protein incubation; 2 h post-probe addition incubation) inhibits recombinant human GST-tagged YTHDC2 YTH-domain protein binding to FAM-labeled m6A-mRNA with an IC₅₀ of 16.84 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 86886-76-2
분자량 261.70
화학식 C₁₄H₁₂ClNO₂
SMILES

O=C(CC1=CC=CC=C1)NC2=CC(Cl)=CC=C2O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yang Z, et al. Deep learning-assisted discovery of a potent and cell-active inhibitor of RNA N⁶-methyladenosine recognition protein YTHDC2. Nat Commun. 2026;17(1):46. Published 2026 Jan 6. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
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YTH-IN-2

All YTHDF Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

YTH-IN-2 Related Classifications

HY-181117 Related Classifications