L-Palmitoylcarnitine chloride
Based on 2 publication(s) in Google Scholar
L-Palmitoylcarnitine chloride, a long-chain acylcarnitine and a fatty acid metabolite, accumulates in the sarcolemma and deranges the membrane lipid environment during ischaemia. L-Palmitoylcarnitine chloride inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2.
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- Pureté : 99.93%
- CAS No.: 18877-64-0
- Formule: C23H46ClNO4
- Masse moléculaire:436.07
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) L-Palmitoylcarnitine chloride
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Activité biologique
Description
IC50 & Target
[1]|
Kir6.2 |
Human Endogenous Metabolite |
In Vitro
L-Palmitoylcarnitine (1 μM) inhibits KATP channel activity, without affecting the single channel conductance, through interaction with Kir6.2. L-Palmitoylcarnitine simultaneously enhances the ATP sensitivity of the channel (IC50 fell from 62 to 30 μM)[1].
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Modulation? of? the? membrane? lipid? environment? caused? by L-Palmitoylcarnitine? alters? the? KATP channel function mainly through the interaction with endogenous PI cascade, especially PIP2[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 18877-64-0
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Appearance Solid
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Masse moléculaire 436.07
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Formule C23H46ClNO4
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Color White to off-white
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SMILES
CCCCCCCCCCCCCCCC(O[C@H](CC(O)=O)C[N+](C)(C)C)=O.[Cl-]
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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Cell Rep Med
Targeting long-chain acylcarnitine accumulation to protect cardiac mitochondrial homeostasis after complete revascularization. [Abstract]2025 Dec 16;6(12):102507. PMID: 41406945 -
Nat Prod Bioprospect
2023 Nov 8;13(1):48. PMID: 37938456
Solvant et solubilité
In Vitro:
H2O : 100 mg/mL (229.32 mM; Need ultrasonic)
DMSO : 50 mg/mL (114.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.08 mg/mL (4.77 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.08 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.08 mg/mL (4.77 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.08 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Pureté et documentation
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Fiche technique (268 KB)
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SDS (393 KB)
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- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.2932 mL | 11.4660 mL | 22.9321 mL | 57.3302 mL |
| 5 mM | 0.4586 mL | 2.2932 mL | 4.5864 mL | 11.4660 mL | |
| 10 mM | 0.2293 mL | 1.1466 mL | 2.2932 mL | 5.7330 mL | |
| 15 mM | 0.1529 mL | 0.7644 mL | 1.5288 mL | 3.8220 mL | |
| 20 mM | 0.1147 mL | 0.5733 mL | 1.1466 mL | 2.8665 mL | |
| 25 mM | 0.0917 mL | 0.4586 mL | 0.9173 mL | 2.2932 mL | |
| 30 mM | 0.0764 mL | 0.3822 mL | 0.7644 mL | 1.9110 mL | |
| 40 mM | 0.0573 mL | 0.2867 mL | 0.5733 mL | 1.4333 mL | |
| 50 mM | 0.0459 mL | 0.2293 mL | 0.4586 mL | 1.1466 mL | |
| 60 mM | 0.0382 mL | 0.1911 mL | 0.3822 mL | 0.9555 mL | |
| 80 mM | 0.0287 mL | 0.1433 mL | 0.2867 mL | 0.7166 mL | |
| 100 mM | 0.0229 mL | 0.1147 mL | 0.2293 mL | 0.5733 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
L-Palmitoylcarnitine chloride Related Classifications
HY-113147A Related Classifications
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