2. GPCR/G Protein
  3. GCGR
  4. Lotiglipron

Lotiglipron  (Synonyms: PF-07081532)

Cat. No.: HY-153865 Purity: 99.68%
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Lotiglipron (PF-07081532) is an orally active GLP-1R agonist. Lotiglipron reduces glucose and body weight, and can be used for research of Type 2 diabetes mellitus (T2DM).

For research use only. We do not sell to patients.

Lotiglipron Chemical Structure

Lotiglipron Chemical Structure

CAS No. : 2401892-75-7

Size Price Stock Quantity
1 mg USD 88 In-stock
5 mg USD 176 In-stock
10 mg USD 265 In-stock
25 mg USD 530 In-stock
50 mg USD 795 In-stock
100 mg USD 1192 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Lotiglipron (PF-07081532) is an orally active GLP-1R agonist. Lotiglipron reduces glucose and body weight, and can be used for research of Type 2 diabetes mellitus (T2DM)[1].

Molecular Weight

575.05

Formula

C31H31ClN4O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]1(C2=CC=C(C=N2)Cl)OC3=C(C4CCN(CC4)CC(N(C5=C6)C[C@@H]7CCO7)=NC5=CC=C6C(O)=O)C=CC=C3O1
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (217.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7390 mL 8.6949 mL 17.3898 mL
5 mM 0.3478 mL 1.7390 mL 3.4780 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7390 mL 8.6949 mL 17.3898 mL 43.4745 mL
5 mM 0.3478 mL 1.7390 mL 3.4780 mL 8.6949 mL
10 mM 0.1739 mL 0.8695 mL 1.7390 mL 4.3474 mL
15 mM 0.1159 mL 0.5797 mL 1.1593 mL 2.8983 mL
20 mM 0.0869 mL 0.4347 mL 0.8695 mL 2.1737 mL
25 mM 0.0696 mL 0.3478 mL 0.6956 mL 1.7390 mL
30 mM 0.0580 mL 0.2898 mL 0.5797 mL 1.4491 mL
40 mM 0.0435 mL 0.2174 mL 0.4347 mL 1.0869 mL
50 mM 0.0348 mL 0.1739 mL 0.3478 mL 0.8695 mL
60 mM 0.0290 mL 0.1449 mL 0.2898 mL 0.7246 mL
80 mM 0.0217 mL 0.1087 mL 0.2174 mL 0.5434 mL
100 mM 0.0174 mL 0.0869 mL 0.1739 mL 0.4347 mL
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Lotiglipron Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lotiglipron2401892-75-7PF-07081532PF07081532PF 07081532GCGRGlucagon ReceptorGlucoseType 2 diabetes mellitusT2DMInhibitorinhibitorinhibit

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