M617

Cat. No.: HY-P1131: FAQs
Data Sheet Handling Instructions

M617 is a selective galanin receptor 1 (GAL1) agonist, with K_is of 0.23 and 5.71 nM for GAL1 and GAL2, respectively. M617, acting through its central GAL1, can promote GLUT4 expression and enhance GLUT4 content in the cardiac muscle of type 2 diabetic rats.

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M617 Chemical Structure

CAS No. : 860790-38-1

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M617 TFA

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M617 TFA In-stock

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Description	M617 is a selective galanin receptor 1 (GAL1) agonist, with K_is of 0.23 and 5.71 nM for GAL1 and GAL2, respectively. M617, acting through its central GAL1, can promote GLUT4 expression and enhance GLUT4 content in the cardiac muscle of type 2 diabetic rats^[1]^[2].
Molecular Weight	2361.65
Formula	C₁₁₂H₁₆₁N₂₉O₂₈
CAS No.	860790-38-1
Sequence	Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Gln-Pro-Pro-Gly-Phe-Ser-Pro-NH2
Sequence Shortening	GWTLNSAGYLLGPQPPGFSPFR-NH2
SMILES	[GWTLNSAGYLLGPQPPGFSPFR-NH2]
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (264 KB) Handling Instructions (2659 KB)
References	[1]. Lundström, L., et al. A Galanin Receptor Subtype 1 Specific Agonist. Int J Pept Res Ther 11, 17–27 (2005). [2]. Fang P, et al. Central injection of GalR1 agonist M617 facilitates GLUT4 expression in cardiac muscle of type 2 diabetic rats. Exp Gerontol. 2015;65:85-89. [Content Brief]

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Keywords:

M617860790-38-1M 617M-617Neuropeptide Y ReceptorNPY receptorGLUT4type2diabeticanti-nociceptioncardiovascularInhibitorinhibitorinhibit

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M617

Other Forms of M617:

Biological Activity

Purity & Documentation

References

Customer Review

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