2. GPCR/G Protein Neuronal Signaling
  3. Neuropeptide Y Receptor
  4. M617

M617 is a selective galanin receptor 1 (GAL1) agonist, with Kis of 0.23 and 5.71 nM for GAL1 and GAL2, respectively. M617, acting through its central GAL1, can promote GLUT4 expression and enhance GLUT4 content in the cardiac muscle of type 2 diabetic rats.

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M617 Chemical Structure

M617 Chemical Structure

CAS No. : 860790-38-1

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Based on 1 publication(s) in Google Scholar

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Description

M617 is a selective galanin receptor 1 (GAL1) agonist, with Kis of 0.23 and 5.71 nM for GAL1 and GAL2, respectively. M617, acting through its central GAL1, can promote GLUT4 expression and enhance GLUT4 content in the cardiac muscle of type 2 diabetic rats[1][2].

Molecular Weight

2361.65

Formula

C112H161N29O28
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Gln-Pro-Pro-Gly-Phe-Ser-Pro-NH2
Sequence Shortening

GWTLNSAGYLLGPQPPGFSPFR-NH2
SMILES

[GWTLNSAGYLLGPQPPGFSPFR-NH2]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (42.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4234 mL 2.1172 mL 4.2343 mL
5 mM 0.0847 mL 0.4234 mL 0.8469 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.4234 mL 2.1172 mL 4.2343 mL 10.5858 mL
5 mM 0.0847 mL 0.4234 mL 0.8469 mL 2.1172 mL
10 mM 0.0423 mL 0.2117 mL 0.4234 mL 1.0586 mL
15 mM 0.0282 mL 0.1411 mL 0.2823 mL 0.7057 mL
20 mM 0.0212 mL 0.1059 mL 0.2117 mL 0.5293 mL
25 mM 0.0169 mL 0.0847 mL 0.1694 mL 0.4234 mL
30 mM 0.0141 mL 0.0706 mL 0.1411 mL 0.3529 mL
40 mM 0.0106 mL 0.0529 mL 0.1059 mL 0.2646 mL
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M617 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

M617860790-38-1M 617M-617Neuropeptide Y ReceptorNPY receptorGLUT4type2diabeticanti-nociceptioncardiovascularInhibitorinhibitorinhibit

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