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Cat. No.: HY-159563

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Mal-va-mac-SN38

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Based on 1 Customer Validation

Mal-va-mac-SN38 is a drug-linker conjugate for ADC. Mal-va-mac-SN38 contains a ADC cytotoxin SN-38 (HY-13704) and a linker (HY-126364). Mal-va-mac-SN38 can rapidly and covalently bind with endogenous albumin in vivo, resulting in the formation of HSA-va-mac-SN38. Mal-va-mac-SN38 demonstrates exceptional stability in human plasma, and has anti-tumor and anti-metastasis effect.

For research use only. We do not sell to patients.

Purity: 97.87%
CAS No.: 2778229-31-3
Formula: C₅₂H₆₁N₇O₁₄S
Molecular Weight:1040.14

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Mal-va-mac-SN38 Chemical Structure

CAS No.: 2778229-31-3

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Use of MCE Products

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One-Stop Platform：From Independent R&D to Pilot-Scale Production

Biological Activity

Description

All Drug-Linker Conjugates for ADC Isoforms :

Chemical Information

CAS No. 2778229-31-3
Appearance Solid
Molecular Weight 1040.14
Formula C₅₂H₆₁N₇O₁₄S
Color Light yellow to yellow
SMILES

O=C(N(COC1=CC=C(N=C(C(N2C3)=CC([C@@](O)(CC)C(OC4)=O)=C4C2=O)C3=C5CC)C5=C1)CCS(=O)(C)=O)OCC6=CC=C(NC([C@@H](NC([C@H](C(C)C)NC(CCCCCN7C(C=CC7=O)=O)=O)=O)C)=O)C=C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (96.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

0.9614 mL

4.8070 mL

9.6141 mL

5 mM

0.1923 mL

0.9614 mL

1.9228 mL

10 mM

0.0961 mL

0.4807 mL

0.9614 mL

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lu Y, et al. Design, synthesis, and biological evaluation of cathepsin B cleavage albumin-binding SN38 prodrug in breast cancer. Bioorg Chem. 2024 Jun;147:107370. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	0.9614 mL	4.8070 mL	9.6141 mL	24.0352 mL
	5 mM	0.1923 mL	0.9614 mL	1.9228 mL	4.8070 mL
	10 mM	0.0961 mL	0.4807 mL	0.9614 mL	2.4035 mL
	15 mM	0.0641 mL	0.3205 mL	0.6409 mL	1.6023 mL
	20 mM	0.0481 mL	0.2404 mL	0.4807 mL	1.2018 mL
	25 mM	0.0385 mL	0.1923 mL	0.3846 mL	0.9614 mL
	30 mM	0.0320 mL	0.1602 mL	0.3205 mL	0.8012 mL
	40 mM	0.0240 mL	0.1202 mL	0.2404 mL	0.6009 mL
	50 mM	0.0192 mL	0.0961 mL	0.1923 mL	0.4807 mL
	60 mM	0.0160 mL	0.0801 mL	0.1602 mL	0.4006 mL
	80 mM	0.0120 mL	0.0601 mL	0.1202 mL	0.3004 mL

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100 mg

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Biological Activity
- Description
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References

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Mal-va-mac-SN38

All Drug-Linker Conjugates for ADC Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Mal-va-mac-SN38 Related Classifications

HY-159563 Related Classifications