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MBX-1066

MBX 1066 is a potent antibacterial agent. MBX 1066 shows inhibition for Mycobacterium tuberculosis. MBX 1066 shows antibacterial activity in mice.

For research use only. We do not sell to patients.

CAS No.: 868971-24-8
Formula: C₂₈H₂₄N₆
Molecular Weight:444.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

MBX-1066 Chemical Structure

CAS No.: 868971-24-8

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Sample (0.1mg)

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

MBX 1066 is a potent antibacterial agent. MBX 1066 shows inhibition for Mycobacterium tuberculosis. MBX 1066 shows antibacterial activity in mice^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	CC₅₀	3 μg/mL Compound: MBX-1066, NSC-317881	Cytotoxicity against human HeLa cells after 3 days by MTS assay in presence of 10% fetal calf serum Cytotoxicity against human HeLa cells after 3 days by MTS assay in presence of 10% fetal calf serum	[PMID: 19635954]
HeLa	CC₅₀	32.5 μg/mL Compound: 1066	Cytotoxicity against human HeLa cells by MTS assay Cytotoxicity against human HeLa cells by MTS assay	[PMID: 24969013]
HeLa	CC₅₀	33 μg/mL Compound: MBX-1066	Cytotoxicity against HeLa cells after 3 days by MTS assay Cytotoxicity against HeLa cells after 3 days by MTS assay	[PMID: 20625154]

In Vitro

MBX 1066 shows cytotoxicity for HeLa cells with a CC₅₀ value of 33 µg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MBX 1066 (1, 10 mg/kg; i.v.; single dose, one hour post infection) shows antibacterial activity and increases the mice survival^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ICR/Swiss Webster mice (Staphylococcus aureus strain NRS384) ^[1]
Dosage:

1, 10 mg/kg
Administration:

I.v.; single dose, one hour post infection
Result:

Increased the survival in a dose-dependent maner.

Chemical Information

CAS No. 868971-24-8
Molecular Weight 444.53
Formula C₂₈H₂₄N₆
SMILES

C1(C2=CC=C(C=C2)C3=CC4=C(C=C(C=C4)C5=NCCN5)N3)=CC6=C(C=C(C=C6)C7=NCCN7)N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Panchal RG, et al. Bis-imidazolinylindoles are active against methicillin-resistant Staphylococcus aureus and multidrug-resistant Mycobacterium tuberculosis. J Antibiot (Tokyo). 2013 Jan;66(1):47-9. [Content Brief]

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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