Menin-MLL inhibitor 33
Menin-MLL inhibitor 33 (compound 15-a) is a potent Menin-MLL inhibitor with an IC50 value of 3.6 nM. Menin-MLL inhibitor 33 shows antiproliferative activity.
For research use only. We do not sell to patients.
- Formula: C39H53FN8O5S
- Molecular Weight:764.95
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Menin-MLL inhibitor 33 (compound 15-a) (1 nM- 10µM; 72 h) inhibits cell growth with a GI50 value of 0.008 µM for MV4-11 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:MV4-11 cells
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Concentration:1 nM- 10µM
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Incubation Time:72 h
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Result:Showed antiproliferative activity with a GI50 value of 0.008 µM.
Chemical Information
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Molecular Weight 764.95
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Formula C39H53FN8O5S
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SMILES
C=CS(=O)(N1CC/C(C1)=C2C[C@@]3(NC\2=O)CC[C@H](CC3)CN4CCC5(CN(C5)C6=NC=NN=C6OC7=CC=C(C=C7C(N(C(C)C)C(C)C)=O)F)CC4)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Menin-MLL inhibitor 33 Related Classifications
HY-163798 Related Classifications
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