Methoxycoronarin D
Methoxycoronarin D can be isolated from Hedychium coronarium J. Koenig and is a potent inhibitor of NF-κB with an IC50 value of 7.3 μM. Methoxycoronarin D is also a selective inhibitor of COX-1 with an IC50 value of 0.9 μM.
For research use only. We do not sell to patients.
- CAS No.: 157528-81-9
- Formula: C21H32O3
- Molecular Weight:332.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | GI50 |
30 μM
Compound: 5
|
Growth inhibition of human A549 cells by Sulforhodamine B assay
Growth inhibition of human A549 cells by Sulforhodamine B assay
|
[PMID: 21106458] |
| HeLa | GI50 |
>100 μM
Compound: 5
|
Growth inhibition of human HeLa cells by Sulforhodamine B assay
Growth inhibition of human HeLa cells by Sulforhodamine B assay
|
[PMID: 21106458] |
| MCF7 | GI50 |
25.3 μM
Compound: 5
|
Growth inhibition of human MCF7 cells by Sulforhodamine B assay
Growth inhibition of human MCF7 cells by Sulforhodamine B assay
|
[PMID: 21106458] |
| RAW264.7 | IC50 |
24.6 μM
Compound: 7
|
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 24 hrs
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production measured after 24 hrs
|
[PMID: 31710213] |
| SK-N-SH | GI50 |
13.6 μM
Compound: 5
|
Growth inhibition of human SK-N-SH cells by Sulforhodamine B assay
Growth inhibition of human SK-N-SH cells by Sulforhodamine B assay
|
[PMID: 21106458] |
Chemical Information
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CAS No. 157528-81-9
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Molecular Weight 332.48
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Formula C21H32O3
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SMILES
C[C@]12CCCC(C)(C)[C@@H]1CCC([C@@H]2C/C=C3CC(OC)OC\3=O)=C
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Synonyms
Coronarin D Me ether
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)