Methyl oleanonate (Synonyms: 3-Oxoolean-12-en-28-oic acid methyl ester)

Cat. No.: HY-N7624 Pureza: 99.81%: Ficha de datos
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Methyl oleanonate is a natural triterpene PPARγ agonist isolated from the species of Pistacia lentiscus var. Chia. Methyl oleanonate is a modified oleanolic acid derivative with anti-cancer effects.

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Methyl oleanonate Estructura química

No. CAS : 1721-58-0

Tamaño	Stock	Cantidad
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
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100 mg	Obtener un presupuesto

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Revisión del cliente

Based on 1 publication(s) in Google Scholar

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•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas PPAR:

Ver todas las isoformas

PPARα PPARβ/δ PPARγ PPAR PPARδ

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Descripciòn

Methyl oleanonate is a natural triterpene PPARγ agonist isolated from the species of Pistacia lentiscus var. Chia^[1]. Methyl oleanonate is a modified oleanolic acid derivative with anti-cancer effects^[2].

IC₅₀ & Target^[1]

PPARγ

Cellular Effect

Cell Line	Type	Value	Description	References
518A2	EC₅₀	4.11 μM Compound: 9	Cytotoxicity against human 518A2 cells assessed as cell survival after 96 hrs by SRB assay Cytotoxicity against human 518A2 cells assessed as cell survival after 96 hrs by SRB assay	[PMID: 26177446]
HT-29	EC₅₀	4.47 μM Compound: 9	Cytotoxicity against human HT-29 cells assessed as cell survival after 96 hrs by SRB assay Cytotoxicity against human HT-29 cells assessed as cell survival after 96 hrs by SRB assay	[PMID: 26177446]
HT-29	IC₅₀	> 100 μM Compound: 3	Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay	[PMID: 24487188]
HeLa	IC₅₀	> 100 μM Compound: 3	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	[PMID: 24487188]
J774.A1	IC₅₀	33.5 μM Compound: 4	Inhibition of LPS-induced NO production in mouse J774A1 cells compound preincubated for 1 hr before LPS treatment by Griess reaction Inhibition of LPS-induced NO production in mouse J774A1 cells compound preincubated for 1 hr before LPS treatment by Griess reaction	[PMID: 25113933]
J774.A1	IC₅₀	82.47 μM Compound: 4	Cytotoxicity against mouse J774A1 cells assessed as cell viability by MTT assay relative to control Cytotoxicity against mouse J774A1 cells assessed as cell viability by MTT assay relative to control	[PMID: 25113933]
MCF7	EC₅₀	5.44 μM Compound: 9	Cytotoxicity against human MCF7 cells assessed as cell survival after 96 hrs by SRB assay Cytotoxicity against human MCF7 cells assessed as cell survival after 96 hrs by SRB assay	[PMID: 26177446]
MCF7	IC₅₀	78.7 μM Compound: 3	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 24487188]
MDA-MB-231	IC₅₀	> 100 μM Compound: 3	Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells after 48 hrs by MTT assay	[PMID: 24487188]
MDA-MB-453	IC₅₀	> 100 μM Compound: 3	Cytotoxicity against human MDA-MB-453 cells after 48 hrs by MTT assay Cytotoxicity against human MDA-MB-453 cells after 48 hrs by MTT assay	[PMID: 24487188]
ME-180	IC₅₀	> 100 μM Compound: 3	Cytotoxicity against human ME180 cells after 48 hrs by MTT assay Cytotoxicity against human ME180 cells after 48 hrs by MTT assay	[PMID: 24487188]
PC-3	IC₅₀	> 100 μM Compound: 3	Cytotoxicity against human PC3 cells after 48 hrs by MTT assay Cytotoxicity against human PC3 cells after 48 hrs by MTT assay	[PMID: 24487188]
RAW264.7	IC₅₀	31.7 μM Compound: 4	Inhibition of LPS-induced NO production in mouse RAW264.7 cells compound preincubated for 1 hr before LPS treatment by Griess reaction Inhibition of LPS-induced NO production in mouse RAW264.7 cells compound preincubated for 1 hr before LPS treatment by Griess reaction	[PMID: 25113933]
RAW264.7	IC₅₀	79.3 μM Compound: 4	Cytotoxicity mouse RAW264.7 cells assessed as cell viability by MTT assay relative to control Cytotoxicity mouse RAW264.7 cells assessed as cell viability by MTT assay relative to control	[PMID: 25113933]

Peso molecular

468.71

Fòrmula

C₃₁H₄₈O₃

No. CAS

1721-58-0

Appearance

Solid

Color

White to off-white

SMILES

CC1(C)C(CC[C@]2(C)[C@@]3([H])CC=C4[C@]5([H])CC(C)(C)CC[C@@](C(OC)=O)5CC[C@](C)4[C@@](C)3CC[C@@]12[H])=O

Structure Classification

Initial Source

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvente y solubilidad

In Vitro:

DMSO : 2.5 mg/mL (5.33 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1335 mL	10.6676 mL	21.3352 mL
5 mM	0.4267 mL	2.1335 mL	4.2670 mL
10 mM	---	---	---

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

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In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 99.81%

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Ficha de datos (274 KB) SDS (251 KB)

COA (252 KB) HNMR (193 KB) RP-HPLC (208 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Rasmus K Petersen, et al. Pharmacophore-driven identification of PPARγ agonists from natural sources. J Comput Aided Mol Des. 2011 Feb;25(2):107-16. [Content Brief]

[2]. Barbara Bednarczyk-Cwynar, et al. Anticancer effect of A-ring or/and C-ring modified oleanolic acid derivatives on KB, MCF-7 and HeLa cell lines. Org Biomol Chem. 2012 Mar 21;10(11):2201-5 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1335 mL	10.6676 mL	21.3352 mL	53.3379 mL
DMSO	5 mM	0.4267 mL	2.1335 mL	4.2670 mL	10.6676 mL

Methyl oleanonate Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methyl oleanonate1721-58-03-Oxoolean-12-en-28-oic acid methyl esterPPARPeroxisome proliferator-activated receptorsAnticancer effectoleanolic acid derivativeMCF-7HeLaPPARγagonistInhibitorinhibitorinhibit

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Methyl oleanonate (Synonyms: 3-Oxoolean-12-en-28-oic acid methyl ester)

Revisión del cliente

Methyl oleanonate Related Antibodies

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Ver todos los productos específicos de isoformas PPAR:

Actividad biológica

Pureza y Documentación

Referencias

Revisión del cliente

Calculadora de molaridad

Calculadora de dilución

Complete Stock Solution Preparation Table

Methyl oleanonate Related Classifications

Keywords:

Productos vistos recientemente:

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SAFETY DATA SHEET (SDS)

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