MK-8527
Based on 1 Customer Validation
MK-8527 is an orally active HIV inhibitor and nucleoside reverse transcriptase translocation inhibitor (NRTTI) with antiviral activity. MK-8527 has a similar inhibitory mechanism to ISL (HY-104012).
For research use only. We do not sell to patients.
- Purity: 99.02%
- CAS No.: 1810869-23-8
- Formula: C13H13ClN4O3
- Molecular Weight:308.72
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Nucleotide Compound Library
HY-L044
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Orally Active Compound Library
HY-L061
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Multi-Target Compound Library
HY-L176
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Drug Repurposing Compound Library Plus
HY-L035P
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Clinical Compound Library Plus
HY-L026P
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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Alkyne Compound Library
HY-L258
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Anti-Infection Compound Library
HY-L002
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Clinical Compound Library
HY-L026
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Antiviral Compound Library
HY-L027
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Drug Repurposing Compound Library
HY-L035
Biological Activity
MK-8527 causes loss of lymphocytes[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1810869-23-8
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Appearance Solid
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Molecular Weight 308.72
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Formula C13H13ClN4O3
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Color White to off-white
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SMILES
OC[C@]1(C#C)[C@@H](O)C[C@H](N2C3=NC(Cl)=NC(N)=C3C=C2)O1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 116.67 mg/mL (377.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Gillespie SW, et al. Islatravir: evaluation of clinical development for HIV and HBV. Expert Opin Investig Drugs. 2024 Feb;33(2):85-93. [Content Brief]
[2]. Liu AY, et al. CROI 2024: Global Epidemiology and Prevention of HIV and Other Sexually Transmitted Diseases. Top Antivir Med. 2024 Jul 17;32(3):447-482. [Content Brief]
[3]. Gunaratne SH, et al. CROI 2024: The Challenges of Sustained Viral Suppression, Advanced HIV Disease, and Ending the HIV Epidemic Targets. Top Antivir Med. 2024 Aug 12;32(4):542-567. [Content Brief]
[4]. Zhernov YV, et al. Microbicides for Topical HIV Immunoprophylaxis: Current Status and Future Prospects. Pharmaceuticals (Basel). 2024 May 22;17(6):668. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2392 mL | 16.1959 mL | 32.3918 mL | 80.9795 mL |
| 5 mM | 0.6478 mL | 3.2392 mL | 6.4784 mL | 16.1959 mL | |
| 10 mM | 0.3239 mL | 1.6196 mL | 3.2392 mL | 8.0980 mL | |
| 15 mM | 0.2159 mL | 1.0797 mL | 2.1595 mL | 5.3986 mL | |
| 20 mM | 0.1620 mL | 0.8098 mL | 1.6196 mL | 4.0490 mL | |
| 25 mM | 0.1296 mL | 0.6478 mL | 1.2957 mL | 3.2392 mL | |
| 30 mM | 0.1080 mL | 0.5399 mL | 1.0797 mL | 2.6993 mL | |
| 40 mM | 0.0810 mL | 0.4049 mL | 0.8098 mL | 2.0245 mL | |
| 50 mM | 0.0648 mL | 0.3239 mL | 0.6478 mL | 1.6196 mL | |
| 60 mM | 0.0540 mL | 0.2699 mL | 0.5399 mL | 1.3497 mL | |
| 80 mM | 0.0405 mL | 0.2024 mL | 0.4049 mL | 1.0122 mL | |
| 100 mM | 0.0324 mL | 0.1620 mL | 0.3239 mL | 0.8098 mL |
MK-8527 Related Classifications
HY-158128 Related Classifications
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