MM 47755
MM 47755 (8-O-Methyltetrangomycin; 6-Deoxy-8-O-methylrabelomycin) is an antibiotic with antibacterial activity. MM 47755 can be isolated from Streptomyces.
For research use only. We do not sell to patients.
- CAS No.: 117620-87-8
- Formula: C20H16O5
- Molecular Weight:336.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
>100 μM
Compound: 4
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Cytotoxicity against human HepG2 cells after 2 days by CellTiter-Glo assay
Cytotoxicity against human HepG2 cells after 2 days by CellTiter-Glo assay
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[PMID: 23025282] |
| HepG2 | IC50 |
18.5 μM
Compound: 4
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Antiplasmodial activity against luciferase-expressing sporozoite of Plasmodium berghei ANKA infected in human HepG2 cells assessed as reduction of parasite load after 2 days
Antiplasmodial activity against luciferase-expressing sporozoite of Plasmodium berghei ANKA infected in human HepG2 cells assessed as reduction of parasite load after 2 days
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[PMID: 23025282] |
| M14 | IC50 |
9.7 μM
Compound: 16
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Cytotoxicity against human M14 cells after 72 hrs by MTS assay
Cytotoxicity against human M14 cells after 72 hrs by MTS assay
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[PMID: 26335269] |
| MDA-MB-468 | IC50 |
27 μM
Compound: 16
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Cytotoxicity against human MDA-MB-468 cells after 72 hrs by MTS assay
Cytotoxicity against human MDA-MB-468 cells after 72 hrs by MTS assay
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[PMID: 26335269] |
| NCI-H226 | IC50 |
4.6 μM
Compound: 16
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Cytotoxicity against human NCI-H226 cells after 72 hrs by MTS assay
Cytotoxicity against human NCI-H226 cells after 72 hrs by MTS assay
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[PMID: 26335269] |
| SF-295 | IC50 |
17 μM
Compound: 16
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Cytotoxicity against human SF295 cells after 72 hrs by MTS assay
Cytotoxicity against human SF295 cells after 72 hrs by MTS assay
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[PMID: 26335269] |
| SF-539 | IC50 |
10 μM
Compound: 16
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Cytotoxicity against human SF539 cells after 72 hrs by MTS assay
Cytotoxicity against human SF539 cells after 72 hrs by MTS assay
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[PMID: 26335269] |
In Vitro
MM 47755 has inhibitory activity against Staphylococcus aureus Smith, S. aureus MS9610 (multi-resistant), Micrococcus luteus PCI 1001, Bacillus subtilis NRRLB-558 with MIC values of 12. 5, 12. 5, 25, 12. 5 μg/mL respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 117620-87-8
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Molecular Weight 336.34
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Formula C20H16O5
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SMILES
O=C1C[C@](C)(O)CC(C1=C2C3=O)=CC=C2C(C4=C3C=CC=C4OC)=O
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Synonyms
8-O-Methyltetrangomycin; 6-Deoxy-8-O-methylrabelomycin
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Structure Classification
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Initial Source
Streptomyces
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
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Bacterial live/dead nucleic-acid viability staining
The LIVE/DEAD bacterial viability staining method is based on differential permeability of nucleic-acid-binding fluorescent dyes, most commonly SYTO 9 and propidium iodide (PI), which enables discrimination of bacterial populations with intact versus compromised cytoplasmic membranes. SYTO 9 penetrates both intact and damaged bacterial membranes and binds nucleic acids to produce green fluorescence, whereas propidium iodide penetrates only cells with compromised membranes and fluoresces red while also reducing SYTO 9 signal through competitive binding and fluorescence interactions. The resulting fluorescence pattern is interpreted as a proxy for membrane integrity, which is widely used as an indicator of bacterial viability in microscopy, flow cytometry, and spectroscopic platforms. However, mechanistic studies show that SYTO 9 and PI interactions involve displacement and fluorescence resonance energy transfer effects, which can influence signal interpretation depending on dye ratios a
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MM 47755 Related Classifications
HY-125163 Related Classifications
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