MNK1/2-IN-6
MNK1/2-IN-6 is a potent and selective MNK1/2 inhibitor with IC50s of 2.3 nM and 3.4 nM for MNK1 and MNK2, respectively. MNK1/2-IN-6 induces apoptosis in a concentration-dependent manner.
For research use only. We do not sell to patients.
- CAS No.: 2771087-94-4
- Formula: C27H24N6O
- Molecular Weight:448.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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MNK1 2.3 nM (IC50) |
MNK2 3.4 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DOHH-2 | IC50 |
0.4092 μM
Compound: II-5
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Antiproliferative activity against human DOHH-2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human DOHH-2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 33971490] |
| TMD8 | IC50 |
0.3896 μM
Compound: II-5
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Antiproliferative activity against human TMD8 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human TMD8 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 33971490] |
MNK1/2-IN-6 (compound II-5) (72 h) shows antiproliferative activity with IC50s of 0.3896µM, 0.4092 µM for TMD-8, DOHH-2 cells, respectively[1].
MNK1/2-IN-6 (0.25, 0.5, 1 µM; 24 h) induces TMD-8 cells apoptosis in a concentration-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:TMD-8, DOHH-2 cells
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Concentration:
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Incubation Time:72 h
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Result:Showed antiproliferative activity with IC50s of 0.39µM, 0.41 µM for TMD-8, DOHH-2 cells, respectively.
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Cell Line:TMD-8 cells
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Concentration:0.25, 0.5, 1 µM
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Incubation Time:24 h
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Result:Induced TMD-8 cells apoptosis in a concentration-dependent manner.
Chemical Information
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CAS No. 2771087-94-4
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Molecular Weight 448.52
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Formula C27H24N6O
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SMILES
N[C@H]1CCCN(C1)C(C2=CC=C(C=C2)C3=NN4C(C5=CC=C6C=NC=CC6=C5)=CN=C4C=C3)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MNK1/2-IN-6 Related Classifications
HY-146735 Related Classifications
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