1. MAPK/ERK Pathway Apoptosis
  2. MNK Apoptosis
  3. MNK1/2-IN-6

MNK1/2-IN-6 

Cat. No.: HY-146735
Handling Instructions

MNK1/2-IN-6 is a potent and selective MNK1/2 inhibitor with IC50s of 2.3 nM and 3.4 nM for MNK1 and MNK2, respectively. MNK1/2-IN-6 induces apoptosis in a concentration-dependent manner.

For research use only. We do not sell to patients.

MNK1/2-IN-6 Chemical Structure

MNK1/2-IN-6 Chemical Structure

CAS No. : 2771087-94-4

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Description

MNK1/2-IN-6 is a potent and selective MNK1/2 inhibitor with IC50s of 2.3 nM and 3.4 nM for MNK1 and MNK2, respectively. MNK1/2-IN-6 induces apoptosis in a concentration-dependent manner[1].

IC50 & Target[1]

MNK1

2.3 nM (IC50)

MNK2

3.4 nM (IC50)

In Vitro

MNK1/2-IN-6 (compound II-5) (72 h) shows antiproliferative activity with IC50s of 0.3896µM, 0.4092 µM for TMD-8, DOHH-2 cells, respectively[1].
MNK1/2-IN-6 (0.25, 0.5, 1 µM; 24 h) induces TMD-8 cells apoptosis in a concentration-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: TMD-8, DOHH-2 cells
Concentration:
Incubation Time: 72 h
Result: Showed antiproliferative activity with IC50s of 0.39µM, 0.41 µM for TMD-8, DOHH-2 cells, respectively.

Apoptosis Analysis[1]

Cell Line: TMD-8 cells
Concentration: 0.25, 0.5, 1 µM
Incubation Time: 24 h
Result: Induced TMD-8 cells apoptosis in a concentration-dependent manner.
Molecular Weight

448.52

Formula

C27H24N6O

CAS No.
SMILES

N[C@H]1CCCN(C1)C(C2=CC=C(C=C2)C3=NN4C(C5=CC=C6C=NC=CC6=C5)=CN=C4C=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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MNK1/2-IN-6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
MNK1/2-IN-6
Cat. No.:
HY-146735
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