MNK1/2-IN-6
MNK1/2-IN-6 is a potent and selective MNK1/2 inhibitor with IC50s of 2.3 nM and 3.4 nM for MNK1 and MNK2, respectively. MNK1/2-IN-6 induces apoptosis in a concentration-dependent manner.
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- CAS No.: 2771087-94-4
- Formule: C27H24N6O
- Masse moléculaire:448.52
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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MNK1 2.3 nM (IC50) |
MNK2 3.4 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| DOHH-2 | IC50 |
0.4092 μM
Compound: II-5
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Antiproliferative activity against human DOHH-2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human DOHH-2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 33971490] |
| TMD8 | IC50 |
0.3896 μM
Compound: II-5
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Antiproliferative activity against human TMD8 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Antiproliferative activity against human TMD8 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 33971490] |
MNK1/2-IN-6 (compound II-5) (72 h) shows antiproliferative activity with IC50s of 0.3896µM, 0.4092 µM for TMD-8, DOHH-2 cells, respectively[1].
MNK1/2-IN-6 (0.25, 0.5, 1 µM; 24 h) induces TMD-8 cells apoptosis in a concentration-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:TMD-8, DOHH-2 cells
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Concentration:
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Incubation Time:72 h
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Result:Showed antiproliferative activity with IC50s of 0.39µM, 0.41 µM for TMD-8, DOHH-2 cells, respectively.
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Cell Line:TMD-8 cells
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Concentration:0.25, 0.5, 1 µM
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Incubation Time:24 h
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Result:Induced TMD-8 cells apoptosis in a concentration-dependent manner.
Chemical Information
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CAS No. 2771087-94-4
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Masse moléculaire 448.52
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Formule C27H24N6O
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SMILES
N[C@H]1CCCN(C1)C(C2=CC=C(C=C2)C3=NN4C(C5=CC=C6C=NC=CC6=C5)=CN=C4C=C3)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MNK1/2-IN-6 Related Classifications
HY-146735 Related Classifications
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