Puberulin
Puberulin is a coumarin compound and an orally effective analgesic. Puberulin is present in Choisya ternata var. Sundance. Puberulin exerts analgesic activity against chemical and heat-induced pain agents in mouse models, and this activity does not involve opioid receptors or muscarinic receptors. Puberulin can be used in the research of neuropathic pain.
For research use only. We do not sell to patients.
- CAS No.: 57419-60-0
- Formula: C16H18O5
- Molecular Weight:290.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Puberulin (25-300 μg/mL) exhibits good linearity in HPLC quantification, as demonstrated by a regression coefficient greater than 0.99[1].
Puberulin is successfully isolated as a colourless crystalline solid from Choisya ternata var. Sundance ethanol extract using countercurrent chromatography, with purity confirmed by HPLC[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Puberulin (0.3-10 mg/kg; p.o.; single dose) exerts antinociceptive activity against Glutamate (HY-14608)-induced pain in male Swiss Webster mice at oral doses of 0.3 mg/kg and 1 mg/kg, but not at 10 mg/kg[1].
Puberulin (10 mg/kg; p.o.; single dose) does not exhibit antinociceptive activity against Capsaicin (HY-10448)-induced pain in male Swiss Webster mice at the 10 mg/kg oral dose[1].
Puberulin (0.3-10 mg/kg; p.o.; single dose) exhibits central antinociceptive activity in male Swiss Webster mice across oral doses of 0.3 mg/kg, 1 mg/kg, and 10 mg/kg, significantly increasing hot plate nociception thresholds[1].
Puberulin (1 mg/kg; p.o.; single dose) exhibits central antinociceptive activity in male Swiss Webster mice at the 1 mg/kg oral dose that is not mediated by opioid receptors, as Naloxone (HY-17417A) does not inhibit its effect[1].
Puberulin (1 mg/kg; p.o.; single dose) exhibits central antinociceptive activity in male Swiss Webster mice at the 1 mg/kg oral dose that is not mediated by muscarinic receptors, as Atropine (HY-B1205) does not inhibit its effect[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss Webster (male, 2 months old, 20-25 g, formalin-induced acute pain model)[1]
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Dosage:0.3 mg/kg; 1 mg/kg; 10 mg/kg
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Administration:p.o.; single dose
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Result:Reduced Formalin-induced neurogenic nociception by 62% at 0.3 mg/kg, 53% at 1 mg/kg, and 68% at 10 mg/kg.
Did not affect the inflammatory pain phase (15-30 minutes post-formalin injection).
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Animal Model:Swiss Webster (male, 2 months old, 20-25 g, glutamate-induced nociception model)[1]
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Dosage:0.3 mg/kg; 1 mg/kg; 10 mg/kg
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Administration:p.o.; single dose
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Result:Inhibited Glutamate-induced nociception at 0.3 mg/kg and 1 mg/kg.
Showed no effect at 10 mg/kg.
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Animal Model:Swiss Webster (male, 2 months old, 20-25 g, hot plate thermal nociception model)[1]
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Dosage:0.3 mg/kg; 1 mg/kg; 10 mg/kg
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Administration:p.o.; single dose
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Result:Significantly increased the nociception threshold, as shown by elevated AUC values relative to vehicle control at 0.3 mg/kg, 1 mg/kg, and 10 mg/kg.
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Animal Model:Swiss Webster (male, 2 months old, 20-25 g, hot plate thermal nociception model, muscarinic receptor mechanism assessment)[1]
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Dosage:1 mg/kg
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Administration:p.o.; single dose
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Result:Atropine (muscarinic receptor antagonist) did not interfere with the antinociceptive effect, as shown by no significant difference in AUC between puberulin-only and puberulin+Atropine groups.
Chemical Information
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CAS No. 57419-60-0
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Molecular Weight 290.31
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Formula C16H18O5
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SMILES
O=C1OC2=C(C=C1)C=C(OC)C(OC/C=C(C)/C)=C2OC
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Puberulin Related Classifications
HY-N19281 Related Classifications
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