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Cat. No.: HY-147838

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Nampt-IN-9

Nampt-IN-9 (Compound 8) is a potent NAMPT inhibitor with anticancer activities. Nampt-IN-9 can be used for pancreatic ductal adenocarcinoma research.

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CAS No.: 2180973-35-5
Formule: C₂₆H₃₃N₃O₄
Masse moléculaire:451.56

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

Nampt-IN-9 Chemical Structure

CAS No.: 2180973-35-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Nampt-IN-9 (Compound 8) is a potent NAMPT inhibitor with anticancer activities. Nampt-IN-9 can be used for pancreatic ductal adenocarcinoma research^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
BXPC-3	IC₅₀	0.004 nM Compound: 8	Antiproliferative activity against human BXPC-3 cells assessed as inhibition of cell growth measured after 72 hrs by XTT assay Antiproliferative activity against human BXPC-3 cells assessed as inhibition of cell growth measured after 72 hrs by XTT assay	[PMID: 35724566]
Jurkat	IC₅₀	0.8 nM Compound: 8	Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth measured after 72 hrs by XTT assay Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth measured after 72 hrs by XTT assay	[PMID: 35724566]
MIA PaCa-2	IC₅₀	0.5 nM Compound: 8	Antiproliferative activity against human MIA PaCa-2 cells assessed as inhibition of cell growth measured after 72 hrs by XTT assay Antiproliferative activity against human MIA PaCa-2 cells assessed as inhibition of cell growth measured after 72 hrs by XTT assay	[PMID: 35724566]
PANC-1	IC₅₀	0.6 nM Compound: 8	Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth measured after 72 hrs by XTT assay Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth measured after 72 hrs by XTT assay	[PMID: 35724566]

In Vitro

Nampt-IN-9 (Compound 8) shows anti-proliferative activity with IC₅₀ values of 0.8, 0.5, 0.004 and 0.6 nM against Jurkat, MIA PaCa-2, BxPC-3, PANC-1 cells, respectively^[1].
Nampt-IN-9 (0-1 μM) blunts NAD⁺ and ATP levels and activates caspase 3 in Jurkat leukemia cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2180973-35-5
Masse moléculaire 451.56
Formule C₂₆H₃₃N₃O₄
SMILES

COC1=CC=CC(OC)=C1C(N2CCC(CC2)CCCCNC(/C=C/C3=CN=CC=C3)=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Bai JF, et al. Identification of new FK866 analogues with potent anticancer activity against pancreatic cancer. Eur J Med Chem. 2022 Jun 2;239:114504. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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