2. Metabolic Enzyme/Protease
  3. NAMPT
  4. Nampt-IN-9

Nampt-IN-9 (Compound 8) is a potent NAMPT inhibitor with anticancer activities. Nampt-IN-9 can be used for pancreatic ductal adenocarcinoma research.

For research use only. We do not sell to patients.

Nampt-IN-9

Nampt-IN-9 Chemical Structure

CAS No. : 2180973-35-5

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Nampt-IN-9 Related Antibodies

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Description

Nampt-IN-9 (Compound 8) is a potent NAMPT inhibitor with anticancer activities. Nampt-IN-9 can be used for pancreatic ductal adenocarcinoma research[1].

Cellular Effect
Cell Line Type Value Description References
BXPC-3 IC50
0.004 nM
Compound: 8
Antiproliferative activity against human BXPC-3 cells assessed as inhibition of cell growth measured after 72 hrs by XTT assay
Antiproliferative activity against human BXPC-3 cells assessed as inhibition of cell growth measured after 72 hrs by XTT assay
[PMID: 35724566]
Jurkat IC50
0.8 nM
Compound: 8
Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth measured after 72 hrs by XTT assay
Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth measured after 72 hrs by XTT assay
[PMID: 35724566]
MIA PaCa-2 IC50
0.5 nM
Compound: 8
Antiproliferative activity against human MIA PaCa-2 cells assessed as inhibition of cell growth measured after 72 hrs by XTT assay
Antiproliferative activity against human MIA PaCa-2 cells assessed as inhibition of cell growth measured after 72 hrs by XTT assay
[PMID: 35724566]
PANC-1 IC50
0.6 nM
Compound: 8
Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth measured after 72 hrs by XTT assay
Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth measured after 72 hrs by XTT assay
[PMID: 35724566]
In Vitro

Nampt-IN-9 (Compound 8) shows anti-proliferative activity with IC50 values of 0.8, 0.5, 0.004 and 0.6 nM against Jurkat, MIA PaCa-2, BxPC-3, PANC-1 cells, respectively[1].
Nampt-IN-9 (0-1 μM) blunts NAD+ and ATP levels and activates caspase 3 in Jurkat leukemia cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nampt-IN-9 Related Antibodies
Molecular Weight

451.56

Formula

C26H33N3O4
CAS No.
SMILES

COC1=CC=CC(OC)=C1C(N2CCC(CC2)CCCCNC(/C=C/C3=CN=CC=C3)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Nampt-IN-9 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nampt-IN-92180973-35-5NAMPTNicotinamide phosphoribosyl transferasePBEFVisfatinpre-B cell-enhancing factorPre-B cell colony enhancing factorpancreatic ductal adenocarcinomaPDACanticancerJurkatMIA PaCa-2BxPC-3PANC-1Inhibitorinhibitorinhibit

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