Nampt-IN-9
Nampt-IN-9 (Compound 8) is a potent NAMPT inhibitor with anticancer activities. Nampt-IN-9 can be used for pancreatic ductal adenocarcinoma research.
For research use only. We do not sell to patients.
- CAS No.: 2180973-35-5
- Formula: C26H33N3O4
- Molecular Weight:451.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BXPC-3 | IC50 |
0.004 nM
Compound: 8
|
Antiproliferative activity against human BXPC-3 cells assessed as inhibition of cell growth measured after 72 hrs by XTT assay
Antiproliferative activity against human BXPC-3 cells assessed as inhibition of cell growth measured after 72 hrs by XTT assay
|
[PMID: 35724566] |
| Jurkat | IC50 |
0.8 nM
Compound: 8
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Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth measured after 72 hrs by XTT assay
Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth measured after 72 hrs by XTT assay
|
[PMID: 35724566] |
| MIA PaCa-2 | IC50 |
0.5 nM
Compound: 8
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Antiproliferative activity against human MIA PaCa-2 cells assessed as inhibition of cell growth measured after 72 hrs by XTT assay
Antiproliferative activity against human MIA PaCa-2 cells assessed as inhibition of cell growth measured after 72 hrs by XTT assay
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[PMID: 35724566] |
| PANC-1 | IC50 |
0.6 nM
Compound: 8
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Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth measured after 72 hrs by XTT assay
Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth measured after 72 hrs by XTT assay
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[PMID: 35724566] |
Nampt-IN-9 (Compound 8) shows anti-proliferative activity with IC50 values of 0.8, 0.5, 0.004 and 0.6 nM against Jurkat, MIA PaCa-2, BxPC-3, PANC-1 cells, respectively[1].
Nampt-IN-9 (0-1 μM) blunts NAD+ and ATP levels and activates caspase 3 in Jurkat leukemia cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2180973-35-5
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Molecular Weight 451.56
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Formula C26H33N3O4
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SMILES
COC1=CC=CC(OC)=C1C(N2CCC(CC2)CCCCNC(/C=C/C3=CN=CC=C3)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nampt-IN-9 Related Classifications
HY-147838 Related Classifications
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